Protein structure prediction from sequence variation Journal Article
| Authors: | Marks, D. S.; Hopf, T. A.; Sander, C. |
| Article Title: | Protein structure prediction from sequence variation |
| Abstract: | Genomic sequences contain rich evolutionary information about functional constraints on macromolecules such as proteins. This information can be efficiently mined to detect evolutionary couplings between residues in proteins and address the long-standing challenge to compute protein three-dimensional structures from amino acid sequences. Substantial progress has recently been made on this problem owing to the explosive growth in available sequences and the application of global statistical methods. In addition to three-dimensional structure, the improved understanding of covariation may help identify functional residues involved in ligand binding, protein-complex formation and conformational changes. We expect computation of covariation patterns to complement experimental structural biology in elucidating the full spectrum of protein structures, their functional interactions and evolutionary dynamics. © 2012 Nature America, Inc. |
| Keywords: | gene sequence; review; three dimensional; protein conformation; protein function; proteins; molecular dynamics; genetic variability; genetic variation; evolution; protein interaction; amino acid sequence; molecular sequence data; models, genetic; computer simulation; models, molecular; conformational transition; amino acids; protein folding; protein structure; ligand binding; evolutionary dynamics; models, chemical; sequence analysis, protein; protein structures; conformational change; functional interaction; three-dimensional structure; structural biology; protein structure prediction; covariation; evolutionary information; explosive growth; full spectrum; genomic sequence; sequence variations |
| Journal Title: | Nature Biotechnology |
| Volume: | 30 |
| Issue: | 11 |
| ISSN: | 1087-0156 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-11-01 |
| Start Page: | 1072 |
| End Page: | 1080 |
| Language: | English |
| DOI: | 10.1038/nbt.2419 |
| PROVIDER: | scopus |
| PUBMED: | 23138306 |
| PMCID: | PMC4319528 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 December 2012" - "CODEN: NABIF" - "Source: Scopus" |
