Chromothripsis: Chromosomes in crisis Journal Article
| Authors: | Jones, M. J. K.; Jallepalli, P. V. |
| Article Title: | Chromothripsis: Chromosomes in crisis |
| Abstract: | During oncogenesis, cells acquire multiple genetic alterations that confer essential tumor-specific traits, including immortalization, escape from antimitogenic signaling, neovascularization, invasiveness, and metastatic potential. In most instances, these alterations are thought to arise incrementally over years, if not decades. However, recent progress in sequencing cancer genomes has begun to challenge this paradigm, because a radically different phenomenon, termed chromothripsis, has been suggested to cause complex intra- and interchromosomal rearrangements on short timescales. In this Review, we review established pathways crucial for genome integrity and discuss how their dysfunction could precipitate widespread chromosome breakage and rearrangement in the course of malignancy. © 2012 Elsevier Inc. |
| Keywords: | mutation; review; nonhuman; dna replication; neoplasms; mitosis; chromosome; telomere; animals; dna repair; apoptosis; protein p53; double stranded dna; gene rearrangement; chromosomal instability; chromosome breakage; chromosome rearrangement; double stranded dna break; medical literature; genome; models, genetic; chromosome aberrations; cost benefit analysis; nucleotide; dna damage checkpoint; chromosome disorder; chromothripsis; telomere shortening |
| Journal Title: | Developmental Cell |
| Volume: | 23 |
| Issue: | 5 |
| ISSN: | 1534-5807 |
| Publisher: | Cell Press |
| Date Published: | 2012-11-13 |
| Start Page: | 908 |
| End Page: | 917 |
| Language: | English |
| DOI: | 10.1016/j.devcel.2012.10.010 |
| PROVIDER: | scopus |
| PUBMED: | 23153487 |
| PMCID: | PMC3514072 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 December 2012" - "CODEN: DCEEB" - "Source: Scopus" - PMCID available 11/13/2013 |
