Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis Journal Article
| Authors: | Busque, L.; Patel, J. P.; Figueroa, M. E.; Vasanthakumar, A.; Provost, S.; Hamilou, Z.; Mollica, L.; Li, J.; Viale, A.; Heguy, A.; Hassimi, M.; Socci, N.; Bhatt, P. K.; Gonen, M.; Mason, C. E.; Melnick, A.; Godley, L. A.; Brennan, C. W.; Abdel-Wahab, O.; Levine, R. L. |
| Article Title: | Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis |
| Abstract: | Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated by X-inactivation analysis, identified somatic TET2 mutations. Recurrence testing identified TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematological malignancies and were associated with alterations in DNA methylation. © 2012 Nature America, Inc. All rights reserved. |
| Journal Title: | Nature Genetics |
| Volume: | 44 |
| Issue: | 11 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-11-01 |
| Start Page: | 1179 |
| End Page: | 1181 |
| Language: | English |
| DOI: | 10.1038/ng.2413 |
| PROVIDER: | scopus |
| PMCID: | PMC3483435 |
| PUBMED: | 23001125 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 3 December 2012" - "CODEN: NGENE" - "Source: Scopus" |
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