Recent advances in the molecular imaging of programmed cell death: Part I-Pathophysiology and radiotracers Journal Article
| Authors: | Blankenberg, F. G.; Strauss, H. W. |
| Article Title: | Recent advances in the molecular imaging of programmed cell death: Part I-Pathophysiology and radiotracers |
| Abstract: | In humans, apoptosis (programmed cell death) is the most common form of cell death after necrosis. Apoptosis is a series of genetically preprogrammed biochemical and morphologic energy-requiring events that, after a specific external or internal stimulus, results in the physiologic disappearance of a cell via its self-disintegration and packaging of its contents into membrane vesicles called apoptotic bodies. Apoptotic bodies can readily be ingested, with their nutrients and even organelles recycled by neighboring cells or phagocytes without local inflammation. In contrast, necrosis is characterized by the primary loss of plasma membrane integrity and the uncontrolled release of a cell's contents, often causing local inflammation, tissue damage, and scarring. Alternate forms of cell death also exist, associated with specific molecular mechanisms involving enzymes, organelles, genes, external stimuli, or blockade of normal cell proliferation. In this review we will briefly outline the molecular mechanisms of apoptosis that can be imaged with radiotracers now under development. COPYRIGHT © 2012 by the Society of Nuclear Medicine and Molecular Imaging, Inc. |
| Keywords: | signal transduction; unclassified drug; nonhuman; pathophysiology; positron emission tomography; animals; cell death; gastrointestinal stromal tumor; imatinib; protein bcl 2; apoptosis; lung non small cell cancer; caspase 3; enzyme activation; enzyme activity; molecular imaging; oncology; drug uptake; isotope labeling; fluorodeoxyglucose f 18; gefitinib; radioactive tracers; tracer; senescence; autophagy; fluorine 18; single photon emission computer tomography; phosphatidylcholine; lipocortin 5; olaparib; carbon 11; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; phosphatidylserine; endoplasmic reticulum stress; programmed cell death; apopep i i 124; isatin derivative; ml 10; n (5,6 dihydro 6 oxo 2 phenanthridinyl) 2 dimethylaminoacetamide |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 53 |
| Issue: | 11 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2012-11-01 |
| Start Page: | 1659 |
| End Page: | 1662 |
| Language: | English |
| DOI: | 10.2967/jnumed.112.108944 |
| PROVIDER: | scopus |
| PUBMED: | 23033360 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 December 2012" - "CODEN: JNMEA" - "Source: Scopus" |
