Discovering modulators of gene expression Journal Article
| Authors: | Babur, O.; Demir, E.; Gonen, M.; Sander, C.; Dogrusoz, U. |
| Article Title: | Discovering modulators of gene expression |
| Abstract: | Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression Modulation) is a probabilistic framework that predicts modulators, their affected targets and mode of action by combining gene expression profiles, protein-protein interactions and transcription factor-target relationships. Using GEM, we correctly predicted a significant number of androgen receptor modulators and observed that most modulators can both act as co-activators and co-repressors for different target genes. © The Author(s) 2010. Published by Oxford University Press. |
| Keywords: | protein function; gene targeting; gene expression profiling; protein protein interaction; transcription factor; transcription, genetic; algorithms; transcription factors; gene expression regulation; gene activation; statistical analysis; algorithm; probability; gene repression; androgen receptor; models, genetic; receptors, androgen; protein interaction mapping |
| Journal Title: | Nucleic Acids Research |
| Volume: | 38 |
| Issue: | 17 |
| ISSN: | 0305-1048 |
| Publisher: | Oxford University Press |
| Date Published: | 2010-09-01 |
| Start Page: | 5648 |
| End Page: | 5656 |
| Language: | English |
| DOI: | 10.1093/nar/gkq287 |
| PUBMED: | 20466809 |
| PROVIDER: | scopus |
| PMCID: | PMC2943625 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Art. No.: gkq287" - "CODEN: NARHA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work