Cord blood transplants: One, two or more units? Journal Article
| Authors: | Avery, S.; Barker, J. N. |
| Article Title: | Cord blood transplants: One, two or more units? |
| Abstract: | Purpose of Review: This review summarizes the current status of double-unit cord blood transplantation (CBT) to improve engraftment, reduce transplant-related mortality, and improve disease-free survival. Recent Findings: Transplantation of cord blood provides a potentially curative therapy for many patients without a suitably human leukocyte antigen-matched related or unrelated donor. Single-unit CBT outcomes have been compromised, however, in adults and larger children by limited cell dose. The introduction of double-unit CBT has improved engraftment and transplant-related mortality in adult patients transplanted for hematologic malignancies, with recent data also suggesting a protection against relapse. These improved outcomes are seen despite only a single unit being responsible for sustained donor hematopoiesis in nearly all patients. The study of double-unit CBT provides unique insights into transplant biology, with emerging data suggesting unit dominance is related to unit viability and unit-versus-unit immune interactions. Multiple unit CBT further serves as a platform to test novel graft manipulations. Summary: The development of double-unit CBT now allows the majority of patients, regardless of size or racial/ethnic background, access to transplant therapy. Ongoing investigation will serve to further improve outcomes and expand the role of CBT in the future. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Keywords: | adult; mortality; review; disease free survival; recurrence risk; cord blood stem cell transplantation; engraftment; hematologic malignancy; nonmyeloablative conditioning; graft versus host reaction; hematopoiesis; graft survival; hla system; allogeneic transplantation; double-unit cord blood transplantation |
| Journal Title: | Current Opinion in Hematology |
| Volume: | 17 |
| Issue: | 6 |
| ISSN: | 1065-6251 |
| Publisher: | Lippincott Williams & Wilkins, Ltd. |
| Date Published: | 2010-11-01 |
| Start Page: | 531 |
| End Page: | 537 |
| Language: | English |
| DOI: | 10.1097/MOH.0b013e32833e5b59 |
| PUBMED: | 20739881 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: COHEF" - "Source: Scopus" |
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