TNM staging of colorectal carcinoma: Issues and caveats Journal Article

  


Authors: Shia, J.; Klimstra, D. S.; Bagci, P.; Basturk, O.; Adsay, N. V.
Article Title: TNM staging of colorectal carcinoma: Issues and caveats
Abstract: The TNM staging system of the American Joint Committee on Cancer and the Union for International Cancer Control provides the most reliable guidelines for the prognostication and treatment of colorectal carcinoma. However, issues and caveats exist in the application of this system, mostly relating to the definition of the staging parameters and the pathologic interpretation of the gross and microscopic findings of the resected specimens. This article highlights some of the major issues in both areas. First, it assesses the definition of selected staging parameters, including pTis, pT4a versus pT4b, tumor deposits/N1c, ypT/ypN, and the TNM for rectal versus anal carcinoma. Second, it discusses major problematic areas in the pathologic interpretation of "pseudoinvasion" versus true invasion, deep pT2 versus superficial pT3, serosal involvement, radial margin, total mesorectal excision specimens, and postneoadjuvant chemoradiation rectal resections. The article also provides a brief discussion about some of the major adjunct histopathologic prognostic factors, such as medullary-type histology and tumor differentiation. © 2012 Elsevier Inc.
Keywords: immunohistochemistry; cancer surgery; survival rate; overall survival; histopathology; cancer adjuvant therapy; disease free survival; cancer staging; lymph node metastasis; antineoplastic agent; neoplasm staging; cell viability; basement membrane; tumor volume; tumor differentiation; clinical protocol; practice guideline; tumor biopsy; cell differentiation; colorectal carcinoma; colorectal neoplasms; podoplanin; practice guidelines as topic; carcinoma; tumor classification; colon; signet ring carcinoma; rectum; anus carcinoma; ajcc; criterion variable; pathological interpretation; staging parameters
Journal Title: Seminars in Diagnostic Pathology
Volume: 29
Issue: 3
ISSN: 0740-2570
Publisher: Elsevier Inc.  
Date Published: 2012-08-01
Start Page: 142
End Page: 153
Language: English
DOI: 10.1053/j.semdp.2012.02.001
PROVIDER: scopus
PUBMED: 23062421
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84867485337&partnerID=40&md5=89b6f69c22e9ac7d6e8253d1dc4250cd
Notes: --- - "Export Date: 2 November 2012" - "CODEN: SDPAE" - "Source: Scopus"
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MSK Authors
  1. Olca Basturk
    352 Basturk
  2. David S Klimstra
    978 Klimstra
  3. Jinru Shia
    717 Shia
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