Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can) Journal Article
| Authors: | Nagel, G.; Stocks, T.; Spath, D.; Hjartaker, A.; Lindkvist, B.; Hallmans, G.; Jonsson, H.; Bjørge, T.; Manjer, J.; Häggström, C.; Engeland, A.; Ulmer, H.; Selmer, R.; Concin, H.; Stattin, P.; Schlenk, R. F. |
| Article Title: | Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can) |
| Abstract: | We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n=578,700; mean age=44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fatal cases of blood cancers occurred. Overall, higher BMI was associated with an increased blood cancer risk. In gender-specific subgroup analyses, BMI was positively associated with blood cancer risk (p=0.002), lymphoid neoplasms (p=0.01), and Hodgkin's lymphoma (p=0.02) in women. Further associations with BMI were found for high-grade B-cell lymphoma (p=0.02) and chronic lymphatic leukemia in men (p=0.05) and women (p=0.01). Higher cholesterol levels were inversely associated with myeloid neoplasms in women (p=0.01), particularly acute myeloid leukemia (p=0.003), and glucose was positively associated with chronic myeloid leukemia in women (p=0.03). In men, glucose was positively associated with risk of high-grade B-cell lymphoma and multiple myeloma, while cholesterol was inversely associated with low-grade B-cell lymphoma. The metabolic syndrome score was related to 48 % increased risk of Hodgkin's lymphoma among women. BMI showed up as the most consistent risk factor, particularly in women. A clear pattern was not found for other metabolic factors. © Springer-Verlag 2012. |
| Keywords: | adult; aged; middle aged; leukemia; acute granulocytic leukemia; major clinical study; cancer risk; follow up; follow-up studies; cancer incidence; prospective study; multiple myeloma; cohort studies; chronic myeloid leukemia; cancer mortality; hodgkin disease; risk assessment; t cell lymphoma; body mass; body mass index; hematologic malignancy; myelodysplastic syndrome; hematologic neoplasms; biomarker; lymphoma; glucose blood level; cholesterol; glucose; triacylglycerol; cholesterol blood level; metabolic syndrome x; triacylglycerol blood level; blood glucose; large cell lymphoma; epidemiology; chronic lymphatic leukemia; follicular lymphoma; blood pressure measurement; myeloproliferative neoplasm |
| Journal Title: | Annals of Hematology |
| Volume: | 91 |
| Issue: | 10 |
| ISSN: | 0939-5555 |
| Publisher: | Springer |
| Date Published: | 2012-10-01 |
| Start Page: | 1519 |
| End Page: | 1531 |
| Language: | English |
| DOI: | 10.1007/s00277-012-1489-z |
| PROVIDER: | scopus |
| PUBMED: | 22588328 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "CODEN: ANHEE" - "Source: Scopus" |
