TGFβ signalling in context Journal Article
| Author: | Massague, J. |
| Article Title: | TGFβ signalling in context |
| Abstract: | The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more than a decade ago. Since then, the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings, and its multifunctional nature and medical relevance have relentlessly come to light. However, an old mystery has endured: how does the context determine the cellular response to TGFβ? Solving this question is key to understanding TGFβ biology and its many malfunctions. Recent progress is pointing at answers. © 2012 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | signal transduction; mitogen activated protein kinase; review; nonhuman; protein domain; neoplasms; animals; microrna; smad protein; transforming growth factor beta; embryonic stem cell; transcription factor; drosophila; cell renewal; genetic transcription; cell differentiation; phosphorylation; phosphatidylinositol 3 kinase; cell lineage; cancer inhibition; dna modification; epigenetics; chromatin; cell membrane; receptors, transforming growth factor beta; smad proteins; cell nucleus; pluripotent stem cell; tumor growth; homeostasis; rna polymerase ii; epithelial-mesenchymal transition; epithelial mesenchymal transition; nucleoporin |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 13 |
| Issue: | 10 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-10-01 |
| Start Page: | 616 |
| End Page: | 630 |
| Language: | English |
| DOI: | 10.1038/nrm3434 |
| PROVIDER: | scopus |
| PUBMED: | 22992590 |
| PMCID: | PMC4027049 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "CODEN: NRMCB" - "Source: Scopus" |
