Chromosomal aberrations by 4-color fluorescence in situ hybridization not detected in spitz nevi of older individuals Journal Article
| Authors: | Horst, B. A.; Fang, Y.; Silvers, D. N.; Busam, K. J. |
| Article Title: | Chromosomal aberrations by 4-color fluorescence in situ hybridization not detected in spitz nevi of older individuals |
| Abstract: | Objective: To investigate whether Spitz nevi with typical histopathological features in older patients demonstrate chromosomal aberrations by 4-color fluorescence in situ hybridization (FISH). Design: Retrospectivemedicalrecord review,withprospective masked histopathological and cytogenetic analyses. Setting: University-affiliated dermatology and dermatopathology setting. Patients: Twenty-five patients 50 years or older with melanocytic nevi showing histopathological features typical of Spitz nevi. Main Outcome Measures: Three dermatopathologists masked to the patients' ages reviewed histopathological sections of melanocytic lesions for features typical of Spitz nevi. FISH was performed on samples with typical histopathological features by a 4-color FISH probe set used for the evaluation ofmalignantmelanocytic neoplasms. Results: None of the study cases showing histopathological features typical of Spitz nevi had detectable chromosomal abnormalities by FISH. Conclusions: Spitz nevi in older patients demonstrate molecular features similar to those of Spitz nevi in younger age groups. The findings of normal karyotypes in combination with typical histopathological features are reassuring of Spitz nevus diagnoses in older patients and suggest no correlation of increased malignant potential with advanced age per se. ©2012 American Medical Association. All rights reserved. |
| Keywords: | adolescent; adult; child; clinical article; controlled study; human tissue; aged; aged, 80 and over; middle aged; retrospective studies; clinical feature; histopathology; prospective studies; in situ hybridization, fluorescence; skin defect; skin neoplasms; age factors; age; chromosome aberration; fluorescence in situ hybridization; melanocytic nevus; skin examination; clinical evaluation; juvenile melanoma; nevus, epithelioid and spindle cell; chromosome aberrations; chromosome analysis; karyotype; polyploidy; single-blind method |
| Journal Title: | Archives of Dermatology |
| Volume: | 148 |
| Issue: | 10 |
| ISSN: | 0003-987X |
| Publisher: | American Medical Association |
| Date Published: | 2012-10-01 |
| Start Page: | 1152 |
| End Page: | 1156 |
| Language: | English |
| DOI: | 10.1001/archdermatol.2012.2267 |
| PROVIDER: | scopus |
| PUBMED: | 23069951 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "CODEN: ARDEA" - "Source: Scopus" |
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