Cytogenetic and mutational analyses of melanocytic tumors Journal Article
| Authors: | Gerami, P.; Busam, K. J. |
| Article Title: | Cytogenetic and mutational analyses of melanocytic tumors |
| Abstract: | Analyses of genetic and genomic alterations of melanocytic tumors have not only led to a better understanding of the pathogenesis of melanocytic tumors but also created new opportunities for improvements in diagnostic accuracy in distinguishing nevus from melanoma, and more effective treatments for patients affected by melanoma. Cytogenetic tests have emerged as a promising ancillary method for the workup of diagnostically problematic melanocytic tumors with ambiguous light microscopic features. Mutation analysis not only is important in treatment decision making but also can be used for improved diagnostic accuracy, staging, and prognosis. © 2012. |
| Keywords: | unclassified drug; oncoprotein; mutation; clinical feature; histopathology; review; cancer localization; cancer staging; diagnostic accuracy; gold standard; sensitivity and specificity; stem cell factor; melanoma; metastasis; nevus; differential diagnosis; cytogenetics; mutational analysis; mutator gene; chromosome aberration; fluorescence in situ hybridization; melanocytic nevus; intermethod comparison; eosin; hematoxylin; clinical effectiveness; gene dosage; point mutation; uvea melanoma; cyclin d1; comparative genomic hybridization; false positive result; b raf kinase; oncogene myc; braf gene; nras protein; molecular pathology; kit gene; oncogene n ras; nodal nevus; cancer prognosis; protein gna11; protein gnaq; ras responsive element binding protein 1; primary nevus |
| Journal Title: | Dermatologic Clinics |
| Volume: | 30 |
| Issue: | 4 |
| ISSN: | 0733-8635 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2012-10-01 |
| Start Page: | 555 |
| End Page: | 566 |
| Language: | English |
| DOI: | 10.1016/j.det.2012.06.015 |
| PROVIDER: | scopus |
| PUBMED: | 23021045 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "CODEN: DRMCD" - "Source: Scopus" |
