Prognostic and predictive roles of KRAS mutation in colorectal cancer Journal Article
| Authors: | Arrington, A. K.; Heinrich, E. L.; Lee, W.; Duldulao, M.; Patel, S.; Sanchez, J.; Garcia-Aguilar, J.; Kim, J. |
| Article Title: | Prognostic and predictive roles of KRAS mutation in colorectal cancer |
| Abstract: | The RAS gene family is among the most studied and best characterized of the known cancer-related genes. Of the three human ras isoforms, KRAS is the most frequently altered gene, with mutations occurring in 17%-25% of all cancers. In particular, approximately 30%-40% of colon cancers harbor a KRAS mutation. KRAS mutations in colon cancers have been associated with poorer survival and increased tumor aggressiveness. Additionally, KRAS mutations in colorectal cancer lead to resistance to select treatment strategies. In this review we examine the history of KRAS, its prognostic value in patients with colorectal cancer, and evidence supporting its predictive value in determining appropriate therapies for patients with colorectal cancer. © 2012 by the authors; licensee MDPI, Basel, Switzerland. |
| Keywords: | signal transduction; cancer survival; primary tumor; unclassified drug; gene mutation; overall survival; review; fluorouracil; advanced cancer; nonhuman; disease marker; drug targeting; capecitabine; cancer radiotherapy; binding affinity; colorectal cancer; progression free survival; microrna; epidermal growth factor receptor; genetic association; gene function; wild type; cetuximab; prediction; carcinogenesis; oncogenes; irinotecan; panitumumab; gene expression regulation; cancer inhibition; oncogene; folinic acid; colon cancer; gene interaction; gene identification; drug response; binding site; down regulation; 3' untranslated region; egfr; kras; oncogene k ras; oxaliplatin; k ras protein; rectum cancer; b raf kinase; ras; epidermal growth factor receptor antibody; drug binding; predictive value; chemoradiotherapy; history of medicine; molecular pathology; disease activity; b raf gene; cancer prognosis; let7; let 7 microrna; microrna 143 |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 13 |
| Issue: | 10 |
| ISSN: | 1422-0067 |
| Publisher: | MDPI |
| Date Published: | 2012-01-01 |
| Start Page: | 12153 |
| End Page: | 12168 |
| Language: | English |
| DOI: | 10.3390/ijms131012153 |
| PROVIDER: | scopus |
| PMCID: | PMC3497263 |
| PUBMED: | 23202889 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "Source: Scopus" |
