Impact of low-dose involved-field radiation therapy on pediatric patients with lymphocyte-predominant Hodgkin lymphoma treated with chemotherapy: A report from the Children's Oncology Group Journal Article
| Authors: | Appel, B. E.; Chen, L.; Buxton, A.; Wolden, S. L.; Hodgson, D. C.; Nachman, J. B. |
| Article Title: | Impact of low-dose involved-field radiation therapy on pediatric patients with lymphocyte-predominant Hodgkin lymphoma treated with chemotherapy: A report from the Children's Oncology Group |
| Abstract: | Background: Treatment of pediatric lymphocyte-predominant Hodgkin lymphoma (LPHL) is controversial but has typically consisted of both chemotherapy and radiation. Radiation therapy is associated with potential late effects in children and adolescents. We examined the impact of radiation therapy on long-term outcome of patients with LPHL treated on CCG-5942, a large pediatric cooperative group study of Hodgkin lymphoma (HL). Procedure: Eighty-two patients with LPHL were registered on CCG-5942. Fifty-two patients (63%) received chemotherapy alone; 29 patients (35%) received chemotherapy followed by involved-field radiation therapy (IFRT). Results: The median follow-up of the LPHL patients is 7.7 years; 63 patients (77%) have >5 years of follow-up. The 5-year event-free survival (EFS) and overall survival (OS) were 97% and 100%. Two relapses occurred, both in patients who did not receive IFRT. There were no significant differences in EFS or OS between patients who received or did not receive IFRT. Conclusions: This subset analysis demonstrates the chemosensitivity of pediatric LPHL. Patients who had a complete response to chemotherapy had an excellent EFS and OS without the addition of radiotherapy. © 2012 Wiley Periodicals, Inc. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; child; event free survival; preschool child; school child; treatment outcome; disease-free survival; survival rate; young adult; major clinical study; overall survival; prednisone; doxorubicin; cancer radiotherapy; cytarabine; methotrexate; drug megadose; follow up; dacarbazine; multiple cycle treatment; etoposide; antineoplastic combined chemotherapy protocols; radiotherapy dosage; cyclophosphamide; vincristine; procarbazine; vinblastine; hodgkin disease; long term care; bleomycin; methylprednisolone; children's oncology group; anthracycline; radiation dose distribution; low energy radiation; hodgkin lymphoma; nodular lymphocyte predominant hodgkin lymphoma; lymphocyte-predominant |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 59 |
| Issue: | 7 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2012-12-15 |
| Start Page: | 1284 |
| End Page: | 1289 |
| Language: | English |
| DOI: | 10.1002/pbc.24258 |
| PROVIDER: | scopus |
| PMCID: | PMC3468707 |
| PUBMED: | 22847767 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "CODEN: PBCEA" - "Source: Scopus" |
