Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms Journal Article

   


Authors: Abdel-Wahab, O.; Tefferi, A.; Levine, R. L.
Article Title: Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms
Abstract: Since the discovery of activating mutations in JAK2 in patients with myeloproliferative neoplasms (MPNs) in 2005, gene discovery efforts have identified additional disease alleles, which can predate or occur subsequent to acquisition of JAK2/MPL mutations. In 2009, somatic copy number loss and mutations in the genes TET2 and ASXL1 were identified in MPN patients. Genetic analysis of MPN patient cohorts with adequate sample size and clear clinical annotation are needed to understand the importance of these mutations on MPN phenotype, risk of transformation to leukemia, response to therapy, and influence on overall survival. © 2012 Elsevier Inc.
Keywords: myeloproliferative disorders; myelofibrosis; unclassified drug; mutation; dna-binding proteins; proto-oncogene proteins; janus kinase 2; pathogenesis; review; nonhuman; cancer patient; protein function; cell compartmentalization; gene function; wild type; hematopoietic cell; hematopoiesis; hematopoietic stem cell; repressor proteins; loss of function mutation; chromosome 11; cd34 selection; myeloid progenitor cell; myeloproliferative neoplasm; knockout mouse; thrombocytosis; polycomb group protein; chromosome 4q; polycythemia vera; drosophila protein; multigene family; stat protein; genetic transformation; extramedullary hematopoiesis; jak2; tet2; asxl1; myeloproliferative neoplasms; dioxygenase; protein additional sex combs like 1; protein ten eleven translocation1; protein ten eleven translocation2
Journal Title: Hematology/Oncology Clinics of North America
Volume: 26
Issue: 5
ISSN: 0889-8588
Publisher: Elsevier Inc.  
Date Published: 2012-10-01
Start Page: 1053
End Page: 1064
Language: English
DOI: 10.1016/j.hoc.2012.07.006
PROVIDER: scopus
PMCID: PMC3459179
PUBMED: 23009937
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84866613593&partnerID=40&md5=b24294460367dbe2b58b810670659759
Notes: --- - "Export Date: 2 November 2012" - "CODEN: HCNAE" - "Source: Scopus"
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MSK Authors
  1. Ross Levine
    775 Levine
  2. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
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