Correlation of dosimetric factors and radiation pneumonitis for non-small-cell lung cancer patients in a recently completed dose escalation study Journal Article


Authors: Yorke, E. D.; Jackson, A.; Rosenzweig, K. E.; Braban, L.; Leibel, S. A.; Ling, C. C.
Article Title: Correlation of dosimetric factors and radiation pneumonitis for non-small-cell lung cancer patients in a recently completed dose escalation study
Abstract: Purpose: To determine dosimetric factors for lung, lung subregions, and heart that correlate with radiation pneumonitis (Radiation Therapy Oncology Group Grade 3 or more) in the 78 evaluable patients from a Phase I dose escalation study (1991-2003) of three-dimensional conformal radiation therapy (3D-CRT) of non-small-cell lung cancer. Methods and Materials: There were 10 <Grade 3 pneumonitis cases within 6 months after treatment. Dose-volume factors analyzed for univariate correlation with <Grade 3 pneumonitis were mean dose (MD), effective uniform dose (d eff), normal tissue complication probability (NTCP), parallel model f dam and V D for 5 ≤ D ≤ 60 Gy for whole, ipsilateral, contralateral, upper and lower halves of the lungs and heart D 05, and mean and maximum doses. Results: The most significant variables (0.005 < p < 0.006) were ipsilateral lung V D for D <20 Gy. Also significant (p < 0.05) for ipsilateral lung were V D for D <50 Gy, MD, f dam and d eff; for total lung V D (D <50 Gy), MD, f dam, d eff and NTCP; for lower lung V D (D <60 Gy), MD, f dam and d eff. All variables for upper and contralateral lung were insignificant, as were heart variables. Conclusions: Previously reported correlations between severe pneumonitis and whole lung V 13 and with other dose-volume factors of total lung and lower lung are confirmed. The most significant correlations were for (V 05-V 13) in ipsilateral lung. © 2005 Elsevier Inc.
Keywords: adult; controlled study; aged; aged, 80 and over; middle aged; major clinical study; cancer radiotherapy; radiation dose; lung non small cell cancer; carcinoma, non-small-cell lung; logistic models; lung neoplasms; radiotherapy dosage; radiotherapy; lung cancer; patient monitoring; correlation analysis; disease severity; statistical significance; dosimetry; lung; radiotherapy, conformal; maximum tolerated dose; biological organs; heart; radiation pneumonia; dosimeters; radiation pneumonitis; normal tissue complications; correlation function; dose-volume histogram; three-dimensional treatment planning; heart variables
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 63
Issue: 3
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 2005-11-01
Start Page: 672
End Page: 682
Language: English
DOI: 10.1016/j.ijrobp.2005.03.026
PUBMED: 15939548
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 99" - "Export Date: 24 October 2012" - "CODEN: IOBPD" - "Source: Scopus"
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MSK Authors
  1. Louise E Braban
    10 Braban
  2. Steven A Leibel
    215 Leibel
  3. Andrew Jackson
    167 Jackson
  4. Ellen D Yorke
    314 Yorke
  5. C Clifton Ling
    303 Ling