Monomorphous angiocentric glioma: A distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma Journal Article
| Authors: | Wang, M.; Tihan, T.; Rojiani, A. M.; Bodhireddy, S. R.; Prayson, R. A.; Iacuone, J. J.; Alles, A. J.; Donahue, D. J.; Hessler, R. B.; Kim, J. H.; Haas, M.; Rosenblum, M. K.; Burger, P. C. |
| Article Title: | Monomorphous angiocentric glioma: A distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma |
| Abstract: | We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the exception of 2, began in childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions that, although centered on the cortex or amygdala, extended into the underlying white matter for a short distance. Histologically, the variably infiltrative tumors were distinctively angiocentric with well-developed perivascular pseudorosettes in some cases. Longitudinal and/or circumferential orientations of perivascular cells were common also. The cells were uniform in their cytologic features from case to case and were bipolar in all but one case. A glial nature was inferred from immunoreactivity for GFAP, and ependymal differentiation was suggested by positivity for EMA in three cases and ultrastructural features in one. Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal. Copyright © 2005 by the American Association of Neuropathologists, Inc. |
| Keywords: | immunohistochemistry; adolescent; adult; child; clinical article; human tissue; preschool child; school child; child, preschool; nuclear magnetic resonance imaging; glioma; brain neoplasms; magnetic resonance imaging; microscopy, electron; glial fibrillary acidic protein; brain cortex; vincristine; cell differentiation; immunoreactivity; histology; carmustine; procarbazine; pediatric; cancer infiltration; ependymoma; seizure; epilepsy; astrocytoma; white matter; hemisphere; cell ultrastructure; amygdaloid nucleus; ca-15-3 antigen; angiocentric; bipolar |
| Journal Title: | Journal of Neuropathology and Experimental Neurology |
| Volume: | 64 |
| Issue: | 10 |
| ISSN: | 0022-3069 |
| Publisher: | Oxford University Press |
| Date Published: | 2005-10-01 |
| Start Page: | 875 |
| End Page: | 881 |
| Language: | English |
| PUBMED: | 16215459 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 62" - "Export Date: 24 October 2012" - "CODEN: JNENA" - "Source: Scopus" |
