DNA looping in gene regulation: From the assembly of macromolecular complexes to the control of transcriptional noise Journal Article

  

Authors:	Vilar, J. M. G.; Saiz, L.
Article Title:	DNA looping in gene regulation: From the assembly of macromolecular complexes to the control of transcriptional noise
Abstract:	The formation of DNA loops by the binding of proteins and protein complexes at distal DNA sites plays a central role in many cellular processes, such as transcription, recombination and replication. Important thermodynamic concepts underlie the assembly of macromolecular complexes on looped DNA. The effects that this process has on the properties of gene regulation extend beyond the traditional view of DNA looping as a mechanism to increase the affinity of regulatory molecules for their cognate sites. Recent developments indicate that DNA looping can also lead to the suppression of cell-to-cell variability, the control of transcriptional noise, and the activation of cooperative interactions on demand. © 2005 Elsevier Ltd. All rights reserved.
Keywords:	dna-binding proteins; review; nonhuman; binding affinity; protein motif; animals; cell division; cell function; protein assembly; protein dna binding; transcription initiation; genetic transcription; transcription, genetic; models, theoretical; gene expression regulation; dna; genetic recombination; transcription regulation; escherichia coli; beta galactosidase; binding site; gene control; thermodynamics; binding sites; nucleic acid conformation; energy metabolism; polymer; regulator protein; macromolecule; macromolecular substances; lactose operon; lac operon; operon; repressor gene; tandem repeat; bacteriophage lambda
Journal Title:	Current Opinion in Genetics and Development
Volume:	15
Issue:	2
ISSN:	0959-437X
Publisher:	Elsevier Inc.
Date Published:	2005-04-01
Start Page:	136
End Page:	144
Language:	English
DOI:	10.1016/j.gde.2005.02.005
PUBMED:	15797196
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-15744393452&partnerID=40&md5=4848ed5d1c4f2d8582c95212093c8f5e
Notes:	--- - "Cited By (since 1996): 69" - "Export Date: 24 October 2012" - "CODEN: COGDE" - "Source: Scopus"

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