Oncogenes come of age Conference Paper

   


Authors: Varmus, H.; Pao, W.; Politi, K.; Podsypanina, K.; Du, Y. C. N.
Title: Oncogenes come of age
Conference Title: 70th Cold Spring Harbor Symposium on Quantitative Biology
Abstract: Mutations of proto-oncogenes are common events in the pathogenesis of cancers, as shown in a wide range of studies during the 30 years since the discovery of these genes. The benefits of novel therapies that target the products of mutant alleles in human cancers, and the demonstrated dependence of cancers in mouse models on continued expression of initiating oncogenes, are especially promising signs that revolutionary improvements in cancer care are possible. Full realization of the promise of targeted therapies, however, will require better definitions of the genotypes of human cancers, new approaches to interrupt the biochemical consequences of oncogenic mutations, and a greater understanding of drug resistance and tumor progression. In this paper, we summarize recent efforts toward these goals in our laboratory and others. © 2005 Cold Spring Harbor Laboratory Press.
Keywords: gene mutation; mutation; pathogenesis; erlotinib; nonhuman; conference paper; neoplasms; adenocarcinoma; phenotype; animals; mice; allele; imatinib; proto oncogene; apoptosis; gene amplification; lung neoplasms; genotype; lung cancer; drug resistance; drug resistance, neoplasm; chronic myeloid leukemia; carcinogenesis; transgenic mouse; oncogenes; protein tyrosine kinase inhibitor; protein kinase inhibitors; cancer genetics; oncogene; gefitinib; neoplasms, experimental; oncogene k ras; tumor growth; doxycycline; oncogene ras; mutant; proto-oncogenes; virus oncogene; genes, erbb-1; tetracycline derivative; oncology ward
Journal Title Cold Spring Harbor Symposia on Quantitative Biology
Volume: 70
Conference Dates: 2005 Jun 1-6
Conference Location: Cold Spring Harbor, NY
ISBN: 0091-7451
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 2005-01-01
Start Page: 1
End Page: 9
Language: English
DOI: 10.1101/sqb.2005.70.039
PUBMED: 16869733
PROVIDER: scopus
PMCID: PMC1791364
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33744780649&partnerID=40&md5=5dd865c85e780ec0efe6b95821b564b7
Notes: --- - "Cited By (since 1996): 11" - "Export Date: 24 October 2012" - "CODEN: CSHSA" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. William Pao
    141 Pao
  2. Katrina Podsypanina
    15 Podsypanina
  3. Katerina A Politi
    23 Politi
  4. Yi-Chieh Du
    6 Du
  5. Harold Varmus
    96 Varmus
Related MSK Work