Shark cartilage: An evidence-based systematic review for the natural standard research collaboration Journal Article

  


Authors: Ulbricht, C.; Basch, E.; Barrette, E. P.; Bent, S.; Boon, H.; Hammerness, P. G.; Smith, M.; Sollars, D.; Szapary, P.; Basch, S. H.; Tsourounis, C.; Hackman, D.
Article Title: Shark cartilage: An evidence-based systematic review for the natural standard research collaboration
Abstract: Shark cartilage has become one of the most commonly recognized supplements in the United States. Growing interest in the shark cartilage derivative AE-941 (Neovastat, Aeterna Laboratories Inc., Canada) occurred when preclinical studies demonstrated antiangiogenic, antitumor, and antiinflammatory properties. Several clinical trials have been conducted using AE-941, and the US Food and Drug Administration granted orphan drug status to the agent in 2002. However, there is currently insufficient evidence in humans to recommend for or against shark cartilage use for any indication.
Keywords: thalidomide; clinical trial; constipation; fatigue; review; alpha interferon; allergy; gastrointestinal symptom; calcium; hypercalcemia; antineoplastic activity; psoriasis; asthenia; dizziness; fever; hyperglycemia; wound healing; hypotension; drug mechanism; systematic review; jaundice; pregnancy; antidiabetic agent; rheumatoid arthritis; antiinflammatory activity; osteoarthritis; kaposi sarcoma; drug dose regimen; dyspepsia; thiazide diuretic agent; beta interferon; troponin i; meta analysis; arthropathy; lactation; matrix metalloproteinase inhibitor; retina macula degeneration; cartilage; consciousness disorder; muscle strength; sensation; chondroitin sulfate; glucosamine sulfate; ae 941; shark; ae-941; haifischknorpel; houtsmuller diet; neovastat; shark fin soup; squalamine; u-955; chondroitin; keratan sulfate; occupational asthma
Journal Title: Journal of Cancer Integrative Medicine
Volume: 3
Issue: 3
ISSN: 1544-6301
Publisher: Society for Integrative Oncology  
Date Published: 2005-01-01
Start Page: 99
End Page: 111
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33644678091&partnerID=40&md5=6d9b9b9a66e711da55f2b7c3b88cda29
Notes: --- - "Export Date: 24 October 2012" - "Source: Scopus"