Current status of dose-dense chemotherapy for breast cancer Journal Article
| Author: | Seidman, A. D. |
| Article Title: | Current status of dose-dense chemotherapy for breast cancer |
| Abstract: | In an effort to improve the effectiveness of chemotherapy for breast cancer, examination of the impact of dose intensity, dose density, and treatment duration may have as much relevance as the specific antineoplastic agents utilized. After several years of pilot feasibility studies of dose-dense chemotherapy regimens, whose delivery has been made safe and feasible by the use of hematopoietic growth factor support (in particular, filgrastim), we now have phase III data demonstrating the advantages of this approach in the adjuvant treatment of breast cancer. © Springer-Verlag 2005. |
| Keywords: | leukemia; acute granulocytic leukemia; clinical trial; bevacizumab; doxorubicin; fluorouracil; cancer combination chemotherapy; cancer growth; drug efficacy; drug safety; antineoplastic agents; paclitaxel; cancer adjuvant therapy; postoperative care; chemotherapy, adjuvant; cancer incidence; prospective studies; breast cancer; drug administration schedule; cyclophosphamide; dose-response relationship, drug; breast neoplasms; docetaxel; febrile neutropenia; chemotherapy induced emesis; feasibility study; pilot study; randomized controlled trials; dosimetry; adjuvant chemotherapy; intermethod comparison; epirubicin; trastuzumab; recombinant granulocyte colony stimulating factor; density; granulocytopenia; myelodysplasia; clinical trials, phase iii; dose density |
| Journal Title: | Cancer Chemotherapy and Pharmacology |
| Volume: | 56 |
| Issue: | Suppl. 1 |
| ISSN: | 0344-5704 |
| Publisher: | Springer |
| Date Published: | 2005-11-01 |
| Start Page: | s78 |
| End Page: | s83 |
| Language: | English |
| DOI: | 10.1007/s00280-005-0109-1 |
| PUBMED: | 16273358 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 24 October 2012" - "CODEN: CCPHD" - "Source: Scopus" |
