Improving rectal cancer outcomes with chemotherapy Journal Article
| Author: | Schrag, D. |
| Article Title: | Improving rectal cancer outcomes with chemotherapy |
| Abstract: | During the last five years there have been significant advances in chemotherapy treatment for metastatic colorectal cancer. With the new drugs that are available, median survival of patients with metastatic disease has increased - from 6 months in the early 1990s to 24 months or longer in 2005. The advances in systemic chemotherapy for colorectal cancer, and the availability of three cytotoxic and two targeted monoclonal antibodies, means that patients currently have a wider array of options than ever before. It is necessary for surgeons, radiation oncologists, and medical oncologists to work collaboratively, communicating well and identifying mutually agreed-upon treatment recommendations, in order to deliver optimal care to rectal cancer patients. This article summarizes important advances in treatment, and reviews multidisciplinary approaches to treatment decision-making in both the adjuvant and metastatic settings. © 2005 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; treatment outcome; cancer surgery; clinical trial; neutropenia; review; bevacizumab; cisplatin; fluorouracil; advanced cancer; cancer combination chemotherapy; diarrhea; drug safety; side effect; capecitabine; cancer adjuvant therapy; cancer radiotherapy; methotrexate; antineoplastic agent; metastasis; sensory neuropathy; mucosa inflammation; neuropathy; 7 ethyl 10 hydroxycamptothecin; antineoplastic activity; cetuximab; irinotecan; rash; drug fatality; drug mechanism; heart infarction; stroke; thromboembolism; folinic acid; colon cancer; vascular endothelial growth factor; drug metabolism; oxaliplatin; rectum carcinoma; hand foot syndrome; digestive system perforation; bone marrow toxicity; epidermal growth factor receptor kinase inhibitor; prodrug; rectal cancer; levamisole; chemotherapeutic agents |
| Journal Title: | Seminars in Colon and Rectal Surgery |
| Volume: | 16 |
| Issue: | 3 |
| ISSN: | 1043-1489 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-09-01 |
| Start Page: | 162 |
| End Page: | 169 |
| Language: | English |
| DOI: | 10.1053/j.scrs.2005.09.008 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 24 October 2012" - "CODEN: SCRSF" - "Source: Scopus" |
