New molecular diagnostic methods in head and neck cancer Journal Article
| Authors: | Rodrigo, J. P.; Ferlito, A.; Suárez, C.; Shaha, A. R.; Silver, C. E.; Devaney, K. O.; Bradley, P. J.; Bocker, J. M.; McLaren, K. M.; Grénman, R.; Rinaldo, A. |
| Article Title: | New molecular diagnostic methods in head and neck cancer |
| Abstract: | Initial cancer evaluation includes assessment of histologic appearance, tumor grading, assessment of lymph node status, and presence of metastasis. However, traditional diagnostic methods such as histopathology and radiology are not sensitive enough to detect small numbers of cancer cells and are limited in their ability to predict response to treatment. Recently, there has been considerable progress in molecular diagnostics in these areas. Using molecular-based technologies, it is now possible to detect cancer early in asymptomatic individuals, identify minimal residual disease at histopathologic normal surgical margins, more precisely assess tumor burden in cancer patients, and more accurately assess the prognosis of the patients. Examples of these applications in the evaluation of head and neck cancer are reviewed here. However, despite the great promise of these new molecular approaches for cancer detection, much of the current technology limits their implementation into routine clinical use. © 2005 Wiley Periodicals, Inc. |
| Keywords: | histopathology; review; lymph node metastasis; cancer diagnosis; lymph nodes; cancer grading; sensitivity and specificity; diagnostic procedure; neoplasm proteins; tumor markers, biological; proteomics; histology; radiology; minimal residual disease; head and neck cancer; head and neck neoplasms; early diagnosis; dna, neoplasm; neoplasm metastasis; rna, neoplasm; dna determination; molecular markers; rna analysis; molecular diagnostic techniques; molecular diagnostic methods |
| Journal Title: | Head & Neck |
| Volume: | 27 |
| Issue: | 11 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2005-11-01 |
| Start Page: | 995 |
| End Page: | 1003 |
| Language: | English |
| DOI: | 10.1002/hed.20257 |
| PUBMED: | 16200629 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 14" - "Export Date: 24 October 2012" - "CODEN: HEANE" - "Source: Scopus" |
