Prolonged survival following salvage surgery for chemorefractory ovarian immature teratoma: A case report and review of the literature Journal Article

  

Authors:	Rezk, Y.; Sheinfeld, J.; Chi, D. S.
Article Title:	Prolonged survival following salvage surgery for chemorefractory ovarian immature teratoma: A case report and review of the literature
Abstract:	Background. Data regarding salvage surgery for ovarian immature teratoma (IT) are lacking despite its established role in the management of chemorefractory testicular germ cell tumors. In this report, a case of advanced IT that was salvaged by secondary cytoreduction following failure of both primary therapy and salvage chemotherapy is described, and the available literature is reviewed. Case. A 28-year-old patient underwent primary cytoreductive surgery followed by platinum-based chemotherapy for stage IIIC, grade 3, ovarian IT. Second-line chemotherapy was administered after residual disease was identified at second-look surgery. Following failure of salvage chemotherapy, aggressive secondary debulking resulted in long-term disease-free survival of over 48 months. Conclusion. There appears to be a distinct role for salvage surgery in selected cases of chemorefractory IT. More studies are needed to further define the subset of patients who benefit most from this management approach. © 2004 Elsevier Inc. All rights reserved.
Keywords:	adult; cancer survival; treatment failure; review; case report; salvage therapy; cisplatin; cancer combination chemotherapy; paclitaxel; cancer staging; cytoreductive surgery; ovarian neoplasms; etoposide; drug resistance, neoplasm; ifosfamide; survival time; minimal residual disease; bleomycin; teratoma; ovary teratoma; second look surgery; salvage surgery; immature teratoma; secondary debulking
Journal Title:	Gynecologic Oncology
Volume:	96
Issue:	3
ISSN:	0090-8258
Publisher:	Elsevier Inc.
Date Published:	2005-03-01
Start Page:	883
End Page:	887
Language:	English
DOI:	10.1016/j.ygyno.2004.11.035
PUBMED:	15721445
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-13844256723&partnerID=40&md5=04dab6c031a7cc11bc57bbe08778b72f
Notes:	--- - "Cited By (since 1996): 6" - "Export Date: 24 October 2012" - "CODEN: GYNOA" - "Source: Scopus"

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