Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility Journal Article
| Authors: | Pitt, S. W.; Zhang, Q.; Patel, D. J.; Al-Hashimi, H. M. |
| Article Title: | Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility |
| Abstract: | The global dynamics of the TAR RNA from HIV-1 bound to two distinctly charged molecules have been characterized by NMR studies of residual dipolar couplings (see picture). While neomycin B (NeoB: +5) arrests global motions in TAR, the small organic molecule acetylpromazine (AcP: +1) does not. Results indicate that electrostatic interactions are critical for arresting global motions in RNA. (Chemical Equation Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | transcription factor; drug design; transcription factors; rna; chemistry; ligand; nuclear magnetic resonance spectroscopy; ligands; conformation; nucleic acid conformation; electricity; human immunodeficiency virus 1; hiv-1; organic compounds; residual dipolar couplings; electrostatic interactions; reaction kinetics; electrostatics; conformation analysis; nmr spectroscopy; charge transfer; acetylpromazine; activating transcription factor; activating transcription factors |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 44 |
| Issue: | 22 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2005-05-30 |
| Start Page: | 3412 |
| End Page: | 3415 |
| Language: | English |
| DOI: | 10.1002/anie.200500075 |
| PUBMED: | 15861447 |
| PROVIDER: | scopus |
| PMCID: | PMC4690522 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 16" - "Export Date: 24 October 2012" - "CODEN: ACIEA" - "Source: Scopus" |
