Cellular hamartoma resembling gastrointestinal stromal tumor: A solid tumor of the pancreas expressing c-kit (CD117) Journal Article
| Authors: | Pauser, U.; Da Silva, M. T. S.; Placke, J.; Klimstra, D. S.; Klöppel, G. |
| Article Title: | Cellular hamartoma resembling gastrointestinal stromal tumor: A solid tumor of the pancreas expressing c-kit (CD117) |
| Abstract: | Solid tumors of the pancreas are usually neoplastic. We report on two adult patients, each with a solid tumor of the pancreas that presented with an unusual histology and seemed to follow a benign course. The tumors, one located in the body and one in the tail, were well demarcated and composed of irregularly arranged but well-differentiated acini and small intralobular and interlobular ducts embedded in predominantly hypocellular fibrotic tissue that contained fascicles of cytologically bland spindle cells. Islets were lacking, but immunohistochemical staining for chromogranin A and insulin revealed individual scattered insulin-producing cells distributed between acinar and ductal cells. The spindle cell component tissue showed coexpression of CD34, c-kit (CD117) and bcl-2. The follow-up (2 and 4 years) of the patients was uneventful. We propose to designate the tumors as 'cellular hamartoma resembling gastrointestinal stromal tumor. © 2005 USCAP, Inc. All rights reserved. |
| Keywords: | immunohistochemistry; adult; protein expression; middle aged; disease course; case report; pancreas resection; follow up; antigen expression; cytology; c-kit; gastrointestinal stromal tumor; cd34 antigen; stem cell factor; stem cell factor receptor; tumor localization; gastrointestinal stromal tumors; protein bcl 2; differential diagnosis; tumor differentiation; relapse; histology; postoperative complication; fibrosis; echography; pancreas duct; pancreas tumor; cellular distribution; insulin; spindle cell; antigens, cd34; proto-oncogene proteins c-bcl-2; acinar cell; hamartoma; bcl-2; chromogranin a; cell composition; pancreatic tumor; cd34; pancreas islet; embedding; pancreatic diseases |
| Journal Title: | Modern Pathology |
| Volume: | 18 |
| Issue: | 9 |
| ISSN: | 0893-3952 |
| Publisher: | Nature Research |
| Date Published: | 2005-09-01 |
| Start Page: | 1211 |
| End Page: | 1216 |
| Language: | English |
| DOI: | 10.1038/modpathol.3800406 |
| PUBMED: | 15803185 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 15" - "Export Date: 24 October 2012" - "CODEN: MODPE" - "Source: Scopus" |
