Molecular biology of opioid analgesia Journal Article
| Author: | Pasternak, G. W. |
| Article Title: | Molecular biology of opioid analgesia |
| Abstract: | Opioids provide excellent pain relief in most patients. Yet the responses of patients to individual opioids can vary markedly, even among the μ opioids. Understanding this variability would greatly enhance our ability to treat patients appropriately. Classical pharmacological studies have long implied the existence of multiple subtypes of μ opioid receptors. More recently, a number of variants of the cloned μ opioid receptor have been described. These variants all show the same selectivity for μ opioids, confirming their classification as μ opioid receptors. Yet, they differ in their functional activation by opioids as well as in their localization within cells and regions in the brain. These multiple μ opioid receptors may help explain the range of responses seen clinically among patients for the various opioid drugs. © 2005 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved. |
| Keywords: | promoter region; exon; drug activity; drug tolerability; drug efficacy; drug potentiation; nonhuman; conference paper; binding affinity; genetic analysis; protein domain; protein localization; protein analysis; animals; pain; opiate; genetic variability; drug potency; drug selectivity; drug receptor binding; molecular cloning; patient care; drug mechanism; spinal cord; drug response; binding site; mouse strain; methadone; morphine; analgesics, opioid; molecular biology; structure analysis; drug sensitivity; analgesia; mu opiate receptor; brain region; receptors, opioid, mu; nociception; gene structure; fentanyl; beta funaltrexamine; diamorphine; morphine 6 glucuronide; opioid receptor; patient; cell; receptor subtype; codeine; naloxonazine; mor-1; drug classification; variation (genetics); mop-1; etonitazene; naloxazone |
| Journal Title: | Journal of Pain and Symptom Management |
| Volume: | 29 |
| Issue: | 5 SUPPL. |
| ISSN: | 0885-3924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-05-01 |
| Start Page: | S2 |
| End Page: | S9 |
| Language: | English |
| DOI: | 10.1016/j.jpainsymman.2005.01.011 |
| PUBMED: | 15907642 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 54" - "Export Date: 24 October 2012" - "CODEN: JPSME" - "Source: Scopus" |
