CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients Journal Article
| Authors: | Nishikawa, H.; Jager, E.; Ritter, G.; Old, L. J.; Gnjatic, S. |
| Article Title: | CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients |
| Abstract: | A proportion of cancer patients naturally develop CD4+ T-helper type 1 (Th1) cell responses to NY-ESO-1 that correlate with anti-NY-ESO-1 serum antibodies. To address the role of T-cell regulation in the control of spontaneous tumor immunity, we analyzed NY-ESO-1-specific Th1 cell induction before or after depletion of CD4+CD25+ T cells in vitro. While Th1 cells were generated in the presence of CD25+ T cells in cancer patients seropositive for NY-ESO-1, seronegative cancer patients and healthy donors required CD25+ T-cell depletion for in vitro induction of NY-ESO-1-specific Th1 cells. In vitro, newly generated NY-ESO-1-specific Th1 cells were derived from naive precursors, whereas preexisting memory populations were detectable exclusively in patients with NY-ESO-1 antibody. Memory populations were less sensitive than naive populations to CD4 +CD25+ regulatory T cells. We propose that CD4 +CD25+ regulatory T cells are involved in the generation and regulation of NY-ESO-1-specific antitumor immunity. © 2005 by The American Society of Hematology. |
| Keywords: | controlled study; protein expression; unclassified drug; human cell; case-control studies; cancer patient; neoplasms; cell proliferation; lymphocyte proliferation; cell protein; membrane proteins; in vitro study; cell assay; lymphocyte differentiation; immune response; regulatory mechanism; antigens, neoplasm; gamma interferon; antigen specificity; cd4-positive t-lymphocytes; t-cell antigen receptor specificity; tumor immunity; cd4 antigen; th1 cell; cytokine release; enzyme linked immunospot assay; memory cell; antibodies, neoplasm; t lymphocyte subpopulation; t lymphocyte activation; lymphocyte depletion; immunologic memory; interleukin 2 receptor alpha; protein antibody; receptors, interleukin-2; th1 cells; seroconversion; interferon type ii; ny eso 1 protein |
| Journal Title: | Blood |
| Volume: | 106 |
| Issue: | 3 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2005-08-01 |
| Start Page: | 1008 |
| End Page: | 1011 |
| Language: | English |
| DOI: | 10.1182/blood-2005-02-0607 |
| PUBMED: | 15840697 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 82" - "Export Date: 24 October 2012" - "CODEN: BLOOA" - "Source: Scopus" |
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