Recent advances in the treatment of acute myeloid leukemia Journal Article
| Authors: | Abdel-Wahab, O.; Levine, R. L. |
| Article Title: | Recent advances in the treatment of acute myeloid leukemia |
| Abstract: | Acute myeloid leukemia (AML) is a disorder with significant molecular and clinical heterogeneity. Although there have been clear advances in the identification of somatic genetic and epigenetic alterations present in the malignant cells of patients with AML, translating this knowledge into an integrated view with an impact on the clinical treatment of AML has been slower to evolve. Recent clinical advances in the treatment of AML include studies demonstrating the benefit of dose-intense daunorubicin therapy in induction chemotherapy for patients of any age. We also review use of the DNA methyltransferase inhibitor azacitidine for treatment of AML in elderly patients as well as a study of global patterns of DNA methylation in patients with AML. Lastly, we review a recent assessment of the role of allogeneic hematopoietic stem cell transplantation in AML in first complete remission. © 2010 Medicine Reports Ltd. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; cell cycle; phosphatase; enzyme activity; cellular distribution; anaphase; microtubule; cell activation; chromosome analysis; muscle spindle; protein kinase; centromere; aurora b kinase; dynein adenosine triphosphatase; mps1 enzyme; cytoplasm vesicle; spindle checkpoint silencing |
| Journal Title: | F1000 Medicine Reports |
| Volume: | 2 |
| ISSN: | 1757-5931 |
| Publisher: | Medicine Reports Ltd |
| Date Published: | 2010-07-22 |
| Start Page: | 55 |
| End Page: | 55 |
| Language: | English |
| DOI: | 10.3410/m2-55 |
| PROVIDER: | scopus |
| PMCID: | PMC2927833 |
| PUBMED: | 20798782 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Art. No.: 55" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
778Levine -
573Abdel-Wahab
Related MSK Work