Long-term survival following treatment of pseudomyxoma peritonei: An analysis of surgical therapy Journal Article
| Authors: | Miner, T. J.; Shia, J.; Jaques, D. P.; Klimstra, D. S.; Brennan, M. F.; Coit, D. G. |
| Article Title: | Long-term survival following treatment of pseudomyxoma peritonei: An analysis of surgical therapy |
| Abstract: | Background Data: Pseudomyxoma peritonei (PMP) is a clinical syndrome with a poorly defined natural history. Relative contributions of tumor biology, patient selection, and the extent of treatment on ultimate outcome are not well characterized. Methods: Patients treated at the Memorial Sloan-Kettering Cancer Center between 1980 and 2002 with a diagnosis of PMP were identified. Patient characteristics, pathologic features, and details of treatment were analyzed retrospectively. Results: The 97 patients included in this study underwent a mean 2.2 ± 0.1 operations (range, 1-6). Although complete cytoreduction was achieved in 55% (53/97), disease recurred in 91% (48/53) of patients. The median disease-free interval after complete cytoreduction was 24 months. The median overall survival was 9.8 years and was independently associated with low-grade pathologic subtype (P < 0.001) and the ability to achieve complete cytoreduction (P < 0.001). Ten-year survival was attained in 21% (20/97) of the patients, of which 90% (18/20) had low-grade pathologic features. At the time of death or completion of follow-up, only 12% (12/97) of the patients were disease free. Conclusions: Outcome in patients with PMP is strongly associated with tumor biology. Although improved survival is associated with low-grade pathology and tumors amenable to complete cytoreduction, recurrence of PMP is common. Treatment may be beneficial, particularly in controlling symptoms, but absolute cure, defined as a prolonged disease-free state, is uncommon. |
| Keywords: | adult; cancer survival; controlled study; aged; aged, 80 and over; disease-free survival; middle aged; cancer surgery; histopathology; splenectomy; patient selection; follow up; hysterectomy; cytoreductive surgery; peritoneal neoplasms; morbidity; adenocarcinoma, mucinous; cancer mortality; survival time; colon resection; gastrectomy; liver resection; colostomy; pseudomyxoma peritonei; peritoneum pseudomyxoma |
| Journal Title: | Annals of Surgery |
| Volume: | 241 |
| Issue: | 2 |
| ISSN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2005-02-01 |
| Start Page: | 300 |
| End Page: | 308 |
| Language: | English |
| DOI: | 10.1097/01.sla.0000152015.76731.1f |
| PUBMED: | 15650641 |
| PROVIDER: | scopus |
| PMCID: | PMC1356916 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 107" - "Export Date: 24 October 2012" - "CODEN: ANSUA" - "Source: Scopus" |
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