Prompt control of bronchorrhea in patients with bronchioloalveolar carcinoma treated with gefitinib (Iressa) Journal Article

  


Authors: Milton, D. T.; Kris, M. G.; Gomez, J. E.; Feinstein, M. B.
Article Title: Prompt control of bronchorrhea in patients with bronchioloalveolar carcinoma treated with gefitinib (Iressa)
Abstract: Bronchorrhea is a condition in which voluminous sputum is produced daily, typically seen with bronchioloalveolar cell carcinoma (BAC). Unless the underlying cancer can be controlled, bronchorrhea causes substantial symptomatic distress. We report two cases of bronchorrhea associated with advanced BAC successfully treated with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, gefitinib. Prompt resolution of these patients' bronchorrhea, dyspnea, and supplemental oxygen requirements are detailed. Given the limited success of alternative interventions, a trial of gefitinib should be considered for patients with bronchorrhea secondary to BAC. © Springer-Verlag 2004.
Keywords: adult; cancer chemotherapy; treatment outcome; aged; middle aged; case report; advanced cancer; antineoplastic agents; cancer patient; disease association; lung neoplasms; oxygen; epidermal growth factor receptor; receptor, epidermal growth factor; protein tyrosine kinase inhibitor; dyspnea; protein kinase inhibitors; gefitinib; lung carcinoma; lung alveolus cell carcinoma; egfr; quinazolines; bronchus disease; oxygen supply; supplementation; adenocarcinoma, bronchiolo-alveolar; sputum; bronchorrhea; bac
Journal Title: Supportive Care in Cancer
Volume: 13
Issue: 1
ISSN: 0941-4355
Publisher: Springer Verlag  
Date Published: 2005-01-01
Start Page: 70
End Page: 72
Language: English
DOI: 10.1007/s00520-004-0717-z
PUBMED: 15558327
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-13244291541&partnerID=40&md5=556d1376df1ec32e257241c1c1e515b3
Notes: --- - "Cited By (since 1996): 11" - "Export Date: 24 October 2012" - "CODEN: SCCAE" - "Source: Scopus"
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MSK Authors
  1. Jorge Gomez
    27 Gomez
  2. Daniel T Milton
    14 Milton
  3. Marc B Feinstein
    41 Feinstein
  4. Mark Kris
    872 Kris
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