Partial-breast radiation for early staged breast cancers: Hypothesis, existing data, and a planned phase III trial Journal Article
| Author: | McCormick, B. |
| Article Title: | Partial-breast radiation for early staged breast cancers: Hypothesis, existing data, and a planned phase III trial |
| Abstract: | This review of clinical data from partial-breast treatment studies discusses results from a single institution's experience using brachytherapy catheters, the MammoSite balloon (Proxima Company, Alpharetta, GA), and three-dimensional external beam partial-breast treatment. Rationale, techniques, dose schedules, and available results are presented. Intra-operative single-dose radiation to the lumpectomy site is also reviewed. The National Surgical Adjuvant Breast and Bowel Project (NSABP) and Radiation Therapy Oncology Group (RTOG) cooperative groups are opening a phase III trial to compare partial-breast treatment to the standard 5- to 6-week course of whole-breast radiation. The design of this study is also presented in this review. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | review; dose response; cancer staging; methodology; neoplasm staging; breast cancer; radiotherapy; pathology; breast neoplasms; instrumentation; intraoperative period; breast tumor; partial mastectomy; catheterization; brachytherapy; phase 3 clinical trial; segmental mastectomy; mastectomy, segmental; breast conservation; beam therapy; partial-breast irradiation; clinical trials, phase iii |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 3 |
| Issue: | 3 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2005-05-01 |
| Start Page: | 301 |
| End Page: | 307 |
| Language: | English |
| PUBMED: | 16002002 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 24 October 2012" - "Source: Scopus" |
