EGFR tyrosine kinase domain mutations in human gliomas Journal Article
| Authors: | Marie, Y.; Carpentier, A. F.; Omuro, A. M. P.; Sanson, M.; Thillet, J.; Hoang-Xuan, K.; Delattre, J. Y. |
| Article Title: | EGFR tyrosine kinase domain mutations in human gliomas |
| Abstract: | Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor effective in patients with lung cancer with mutations in exons 19 and 21 of the EGFR tyrosine kinase domain. In this study, the authors tested the presence of such mutations in 95 gliomas including glioblastomas, anaplastic oligodendrogliomas, and low-grade gliomas. No mutation was found, which suggests that the biology of EGFR in gliomas is different from lung cancer and that this may be a factor in the resistance of glioblastomas to gefitinib. Copyright © 2005 by AAN Enterprises, Inc. |
| Keywords: | controlled study; treatment outcome; major clinical study; mutation; drug efficacy; glioma; brain neoplasms; protein domain; lung neoplasms; receptor, epidermal growth factor; drug resistance, neoplasm; mutational analysis; protein kinase inhibitors; glioblastoma; gefitinib; carcinoma; oligodendroglioma; protein structure, tertiary; cancer tissue; dna mutational analysis; quinazolines; genetic screening; astrocytoma; anaplastic carcinoma; epidermal growth factor receptor kinase; epidermal growth factor receptor kinase inhibitor; drug indication; brain tissue |
| Journal Title: | Neurology |
| Volume: | 64 |
| Issue: | 8 |
| ISSN: | 0028-3878 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2005-04-26 |
| Start Page: | 1444 |
| End Page: | 1445 |
| Language: | English |
| PUBMED: | 15851741 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 52" - "Export Date: 24 October 2012" - "CODEN: NEURA" - "Source: Scopus" |
