Body mass index is weakly associated with, and not a helpful predictor of, disease progression in men with clinically localized prostate carcinoma treated with radical prostatectomy Journal Article
| Authors: | Mallah, K. N.; DiBlasio, C. J.; Rhee, A. C.; Scardino, P. T.; Kattan, M. W. |
| Article Title: | Body mass index is weakly associated with, and not a helpful predictor of, disease progression in men with clinically localized prostate carcinoma treated with radical prostatectomy |
| Abstract: | BACKGROUND. Several studies have recently suggested an association between body mass index (BMI) and disease progression after radical prostatectomy. In the current study, the authors examined this association and that between the reciprocal of BMI (INVBMI, 1/BMI) and progression-free probability in men treated with radical retropubic prostatectomy (RRP) for clinically localized prostate carcinoma. METHODS. The authors retrospectively studied 2210 patients who underwent RRP at Memorial Sloan-Kettering Cancer Center between September 1986 and May 2003. Clinicopathologic variables analyzed included BMI (kg/m 2), preoperative serum prostate-specific antigen level (ng/mL), clinical T classification, year of surgery, race, biopsy-derived primary and secondary Gleason grades, and INVBMI, known to better correlate with percent body fat than BMI. Cox regression analysis was used to examine the possible association between BMI or its reciprocal with disease progression after controlling for the effects of common prognostic factors. The areas under the receiver operating curve (AUC) for models with and without INVBMI were calculated RESULTS. Of the 2210 patients analyzed, 251 experienced disease progression in a median follow-up time of 25.9 months (range, 0-143 months). After adjusting for all clinical variables, both BMI (P = 0.071; hazards ratio [HR] = 1.027) and INVBMI (P = 0.041; HR < 0.001) were associated with disease progression. However, the areas under AUC for models with and without INVBMI were similar (range, 0.794-0.798). CONCLUSIONS. Although conflicting evidence has been reported regarding the link between obesity and an increased risk of developing prostate carcinoma, as well as an increased risk of developing aggressive disease and prostate carcinoma-related mortality, the authors found weak associations with disease progression for both BMI and INVBMI. These variables were of negligible prognostic value in men who received surgery. Studies with longer follow-up, that examine alternative end points, and that follow treatment(s) besides surgery are needed. © 2005 American Cancer Society. |
| Keywords: | retrospective studies; major clinical study; clinical feature; area under the curve; cancer growth; cancer risk; united states; follow up; follow-up studies; neoplasm staging; cancer grading; preoperative evaluation; prostate specific antigen; cohort studies; neoplasm recurrence, local; obesity; tumor biopsy; retrospective study; prediction; risk factor; biopsy; cancer mortality; prostate-specific antigen; prostatic neoplasms; body mass; correlation analysis; body mass index; probability; prostatectomy; disease progression; carcinoma; forecasting; area under curve; roc curve; race; prostate carcinoma; calculation; continental population groups; radical retropubic prostatectomy; body fat; reciprocal of body mass index |
| Journal Title: | Cancer |
| Volume: | 103 |
| Issue: | 10 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2005-05-15 |
| Start Page: | 2030 |
| End Page: | 2034 |
| Language: | English |
| DOI: | 10.1002/cncr.20991 |
| PUBMED: | 15822118 |
| PROVIDER: | scopus |
| PMCID: | PMC1852497 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 46" - "Export Date: 24 October 2012" - "CODEN: CANCA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work