AM3 inhibits LPS-induced iNOS expression in mice Journal Article
| Authors: | Majano, P.; Alonso-Lebrero, J. L.; Jańczyk, A.; Martín-Vichez, S.; Molina-Jiménez, F.; Brieva, A.; Pivel, J. P.; Gonzalez, S.; López-Cabrera, M.; Moreno-Otero, R. |
| Article Title: | AM3 inhibits LPS-induced iNOS expression in mice |
| Abstract: | We have analyzed the effect of a patented glycoconjugate of natural origin, AM3 (commercially available under the name Inmunoferon®) in the expression of iNOS induced by administration of LPS in mice. We have observed that oral treatment with the drug daily for 6 days reduced the levels of expression of iNOS induced by an intravenous pulse of LPS. This effect was significant in the lungs and kidneys, but it was much more marked in the liver. In addition, the levels of nitric oxide in serum were clearly decreased upon treatment with AM3. Together, these results suggest that AM3 modulates the nitric oxide response and points to a possible role for AM3 in the control of the inflammatory response. © 2005 Elsevier B.V. All rights reserved. |
| Keywords: | controlled study; protein expression; drug efficacy; nonhuman; mouse; animals; mice; animal tissue; gene expression; animal experiment; animal model; inflammation; mice, inbred balb c; statistical significance; tumor necrosis factor-alpha; lipopolysaccharide; inhibition kinetics; rats; glycopeptides; kidney parenchyma; nitric oxide synthase; inducible nitric oxide synthase; nitric oxide synthase type ii; rats, inbred lew; nitric oxide; lung parenchyma; anti-inflammatory agents; lipopolysaccharides; calcium phosphates; inos; am3; anti-inflammatory response; inmunoferon; immunoferon; endotoxemia |
| Journal Title: | International Immunopharmacology |
| Volume: | 5 |
| Issue: | 7-8 |
| ISSN: | 1567-5769 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2005-07-01 |
| Start Page: | 1165 |
| End Page: | 1170 |
| Language: | English |
| DOI: | 10.1016/j.intimp.2005.02.009 |
| PUBMED: | 15914321 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 24 October 2012" - "CODEN: IINMB" - "Source: Scopus" |
