The transcription factor Pokemon: A new key player in cancer pathogenesis Journal Article
| Authors: | Maeda, T.; Hobbs, R. M.; Pandolfi, P. P. |
| Article Title: | The transcription factor Pokemon: A new key player in cancer pathogenesis |
| Abstract: | Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics. ©2005 American Association for Cancer Research. |
| Keywords: | unclassified drug; dna-binding proteins; review; drug targeting; protein function; animals; mice; gene overexpression; transcription factor; carcinogenesis; transcription factors; cell transformation, neoplastic; dimerization; tumor suppressor protein; malignant transformation; transcription factor pokemon; tumor suppressor arf |
| Journal Title: | Cancer Research |
| Volume: | 65 |
| Issue: | 19 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2005-10-01 |
| Start Page: | 8575 |
| End Page: | 8578 |
| Language: | English |
| DOI: | 10.1158/0008-5472.can-05-1055 |
| PUBMED: | 16204018 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 47" - "Export Date: 24 October 2012" - "CODEN: CNREA" - "Source: Scopus" |
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