PET/CT in non-small-cell lung cancer: Value of respiratory-gated PET Journal Article
| Authors: | Larson, S. M.; Nehmeh, S. A.; Erdi, Y. E.; Humm, J. L. |
| Article Title: | PET/CT in non-small-cell lung cancer: Value of respiratory-gated PET |
| Abstract: | The use of PET in the staging of patients with NSCLC is cost-effective, mainly due to a reduction in the number of futile operations. The addition of SUVmax to pathologic tumor size identifies a subgroup of patients at highest risk for death as a result of recurrent disease after resection. Tumor staging is more accurate with PET-CT than with CT alone or with PET alone. The greatest source of error in accurate localization and quantification on PET or PET-CT in lung cancer is respiratory motion. At MSKCC respiratory-gated PET (RGPET) is used in treatment planning. The lesion in the gated image is smaller in diameter than in the ungated image. Respiratory-correlated dynamic PET (RCDPET) can be considered an alternative method to RGPET. RCDPET shows very accurate local co-registration that can be used to make an attenuation correction and obtain an SUV. Gating gives a much clearer picture resulting in more than a one-third increase in the quantification. The SUV of lung lesions must be re-evaluated based on these techniques. This development will have important implications in areas such as the liver for controlling respiratory motion, which is a major problem in terms of lesion detection. We have successfully taken the first step in an attempt to correct for respiratory motion artifacts in PET imaging of lung lesions. |
| Keywords: | cancer surgery; review; cancer localization; cancer recurrence; cancer risk; treatment planning; cancer staging; positron emission tomography; cancer diagnosis; neoplasm staging; diagnostic accuracy; computer assisted tomography; tumor volume; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; tomography, x-ray computed; diagnostic imaging; cancer therapy; high risk patient; cost effectiveness analysis; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; cost-benefit analysis; breathing mechanics; lung injury; fluoro-2-deoxy-d-glucose (fdg); non-small-cell lung cancer (nsclc); respiratory-correlated dynamic pet (rcdpet); respiratory-gated pet (rgpet) |
| Journal Title: | Chang Gung Medical Journal |
| Volume: | 28 |
| Issue: | 5 |
| ISSN: | 0255-8270 |
| Publisher: | Medknow Publications |
| Date Published: | 2005-05-01 |
| Start Page: | 306 |
| End Page: | 314 |
| Language: | English |
| PUBMED: | 16086545 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 24 October 2012" - "CODEN: CIHCE" - "Source: Scopus" |
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