Acute renal failure in cancer patients Journal Article
| Authors: | Lameire, N. H.; Flombaum, C. D.; Moreau, D.; Ronco, C. |
| Article Title: | Acute renal failure in cancer patients |
| Abstract: | Acute renal failure (ARF) is defined as a sudden decrease in glomerular filtration rate leading to an acute rise in blood urea nitrogen and serum creatinine levels. It is a serious complication of cancer and constitutes a major source of morbidity and mortality. Current data suggest that ARF has the potential to substantially jeopardize the chances of cancer patients receiving optimal treatment and a potential cure. The pathways leading to ARF in cancer patients are common to the development of ARF in other conditions. However, ARF may also develop due to aetiologies arising from cancer treatment or the disease itself, including: nephrotoxic chemotherapy agents, post-renal obstruction, compression and infiltration by malignancy, tumour lysis syndrome, uric acid, sepsis and contrast agent nephropathy. This review provides a comprehensive overview of the causes of ARF in patients with cancer and guidance on how to prevent and treat this condition. Ultimately, the key to managing ARF in cancer patients is to ensure that a multidisciplinary approach provides adequate assessment, appropriate preventative measures and early intervention. © 2005 Taylor & Francis Ltd. |
| Keywords: | osteosarcoma; acute granulocytic leukemia; mortality; review; cisplatin; hypertension; hypophosphatemia; antineoplastic agents; gemcitabine; cancer patient; methotrexate; drug megadose; antineoplastic agent; neoplasms; carboplatin; unindexed drug; multiple myeloma; nephrotoxicity; anemia; thrombocytopenia; risk factors; aciclovir; steroid; hematopoietic stem cell transplantation; carmustine; ifosfamide; lomustine; acute lymphoblastic leukemia; hyperuricemia; hypomagnesemia; sarcoma; tumor lysis syndrome; acute kidney failure; hypokalemia; hyponatremia; nonhodgkin lymphoma; systematic review; prophylaxis; sepsis; mitomycin c; contrast medium; drug metabolism; oxaliplatin; chronic lymphatic leukemia; hemodialysis; hemolytic uremic syndrome; thrombotic thrombocytopenic purpura; uric acid; foscarnet; burkitt lymphoma; chronic kidney failure; nephrotic syndrome; pentostatin; zoledronic acid; gemtuzumab ozogamicin; streptozocin; drug elimination; pamidronic acid; allopurinol; urinary tract obstruction; rasburicase; kidney failure, acute; aminoglycoside antibiotic agent; bicarbonate; fanconi renotubular syndrome; metabolic acidosis; acetylcysteine; amphotericin b; semustine; renal protection; glucosuria; 7 hydroxymethotrexate; aspergillus flavus; acute renal failure; tumour lysis syndrome; urate oxidase; aminoaciduria; hyperchloremic acidosis; phosphaturia; renal diabetes; salt losing nephritis |
| Journal Title: | Annals of Medicine |
| Volume: | 37 |
| Issue: | 1 |
| ISSN: | 0785-3890 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2005-01-01 |
| Start Page: | 13 |
| End Page: | 25 |
| Language: | English |
| DOI: | 10.1080/07853890510007205 |
| PUBMED: | 15902843 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 29" - "Export Date: 24 October 2012" - "CODEN: ANMDE" - "Source: Scopus" |
