Correlation of HER-2 status with estrogen and progesterone receptors and histologic features in 3,655 invasive breast carcinomas Journal Article
| Authors: | Lal, P.; Tan, L. K.; Chen, B. |
| Article Title: | Correlation of HER-2 status with estrogen and progesterone receptors and histologic features in 3,655 invasive breast carcinomas |
| Abstract: | We studied the inverse relationship between HER-2 and estrogen (ER) and progesterone (PR) receptors using HER-2 testing and correlated HER-2 status with histologic features in 3,655 unselected invasive breast carcinomas. Immunohistochemical analysis for ER, PR, and HER-2 and fluorescence in situ hybridization for HER-2 were performed. ER and PR expression were decreased significantly in HER-2+ tumors compared with HER-2- tumors (ER, 49.1% vs 78.17%; PR, 24.3% vs 53.13%). Even among HER-2+ tumors, the rate of ER or PR expression in high-grade tumors was significantly decreased compared with intermediate-grade tumors. HER-2 was positive in 10.87% of grade 2 and 27.84% of grade 3 ductal carcinomas and negative in all grade 1 ductal carcinomas. HER-2 overexpression or amplification essentially was limited to grades 2 and 3 ductal carcinomas and correlated inversely with ER or PR expression. Although ER or PR expression is decreased in HER-2+ tumors, a substantial proportion of them still express ER or PR. |
| Keywords: | immunohistochemistry; controlled study; human tissue; protein expression; in situ hybridization, fluorescence; gene overexpression; gene amplification; epidermal growth factor receptor 2; breast neoplasms; histology; cancer invasion; fluorescence in situ hybridization; breast carcinoma; receptor, erbb-2; receptors, estrogen; receptors, progesterone; estrogen receptor; progesterone receptor; fish; c-erbb-2; her-2/neu |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 123 |
| Issue: | 4 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2005-04-01 |
| Start Page: | 541 |
| End Page: | 546 |
| Language: | English |
| DOI: | 10.1309/ymj3-a83t-b39m-rut9 |
| PUBMED: | 15743737 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 55" - "Export Date: 24 October 2012" - "CODEN: AJCPA" - "Source: Scopus" |
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