Ovarian carcinoma screening in women at intermediate risk: Impact on quality of life and need for invasive follow-up Journal Article


Authors: Kauff, N. D.; Hurley, K. E.; Hensley, M. L.; Robson, M. E.; Lev, G.; Goldfrank, D.; Castiel, M.; Brown, C. L.; Ostroff, J. S.; Hann, L. E.; Offit, K.; Barakat, R. R.
Article Title: Ovarian carcinoma screening in women at intermediate risk: Impact on quality of life and need for invasive follow-up
Abstract: BACKGROUND. Women with family histories suggestive of an increased risk of ovarian carcinoma who have not had a deleterious BRCA1 or BRCA2 mutation identified are commonly suggested to consider ovarian carcinoma screening with transvaginal ultrasound and/or assessment of CA 125 levels. Limited information is available regarding the impact of this approach on either quality of life (QOL) or need for invasive follow-up in this group of women. METHODS. From November 1999 to October 2002, 184 women at intermediate risk of ovarian carcinoma were enrolled in a prospective study. Participants were screened with twice yearly transvaginal ultrasound and CA 125 assessments. Impact on QOL was measured using the Mental Component Summary (MCS) score of the Medical Outcomes Studies Short Form-36. Need for invasive follow-up was determined by questionnaire and medical record review. RESULTS. In the current study, 135 participants underwent ≥ 1 follow-up assessment. During a mean of 19.8 months of follow-up, 12.9% of ultrasounds and 3.8% of CA 125 assessments were abnormal. The authors reported that 38.5% of participants had ≥ 1 abnormal ovarian screen that required a short interval follow-up. Because of either abnormal bleeding or ultrasound abnormalities, 24% of participants underwent ≥ 1 endometrial sampling. Controlling for a history of breast carcinoma and menopausal status, abnormal ovarian screening results were associated with a decrease in MCS score (P = 0.034), whereas the need for endometrial sampling was not (P = 0.87). CONCLUSIONS. Ovarian carcinoma screening in women at intermediate risk was associated with a substantial rate of abnormal screen results, endometrial sampling, and in women with abnormal ovarian screening findings, a decrease in MCS scores. These findings may have important implications for women considering ovarian carcinoma screening and for the design of future ovarian carcinoma screening trials. © 2005 American Cancer Society.
Keywords: adult; human tissue; middle aged; gene mutation; major clinical study; follow up; follow-up studies; prospective studies; ovarian neoplasms; family health; genetic predisposition to disease; quality of life; cancer screening; ultrasound; risk assessment; questionnaire; oncogene; screening; family history; antigen detection; breast carcinoma; medical record; ovary carcinoma; ovarian carcinoma; ca 125 antigen; ca-125 antigen; short form 36; menopause; endometrium biopsy; ultrasonography, interventional; transvaginal echography; ca 125; familial risk; ovarian bleeding
Journal Title: Cancer
Volume: 104
Issue: 2
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2005-07-15
Start Page: 314
End Page: 320
Language: English
DOI: 10.1002/cncr.21148
PUBMED: 15948173
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 11" - "Export Date: 24 October 2012" - "CODEN: CANCA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Gali Lev
    4 Lev
  2. Kenneth Offit
    509 Offit
  3. Richard R Barakat
    588 Barakat
  4. Jamie S Ostroff
    208 Ostroff
  5. Carol Brown
    116 Brown
  6. Mark E Robson
    365 Robson
  7. Mercedes Castiel
    18 Castiel
  8. Noah Kauff
    122 Kauff
  9. Martee L Hensley
    220 Hensley
  10. Karen E Hurley
    45 Hurley
  11. Lucy E Hann
    67 Hann