Risk of ovarian cancer in BRCA1 and BRCA2 mutation-negative hereditary breast cancer families Journal Article
| Authors: | Kauff, N. D.; Mitra, N.; Robson, M. E.; Hurley, K. E.; Chuai, S.; Goldfrank, D.; Wadsworth, E.; Lee, J.; Cigler, T.; Borgen, P. I.; Norton, L.; Barakat, R. R.; Offit, K. |
| Article Title: | Risk of ovarian cancer in BRCA1 and BRCA2 mutation-negative hereditary breast cancer families |
| Abstract: | Women from site-specific hereditary breast cancer families who carry a BRCA1 or BRCA2 mutation are at increased risk for ovarian cancer. It is less clear, however, whether individuals from hereditary breast cancer families who do not carry such a mutation are also at increased ovarian cancer risk. To determine whether women from BRCA mutation-negative hereditary breast cancer families are at increased risk for ovarian cancer, 199 probands from BRCA mutation-negative, site-specific breast cancer kindreds who consented to prospective follow-up at the time of genetic testing were identified. The incidence of new breast and ovarian cancers in probands and their families since receipt of their genetic test results was determined by questionnaire. The expected number of cancers and standardized incidence ratios (SIRs) were determined from age-specific cancer incidence rates from the Surveillance, Epidemiology, and End Results (SEER) program by using the method of Byar. All statistical tests were two-sided. During 2534 women-years of follow-up in 165 kindreds, 19 new cases of breast cancer were diagnosed, whereas only 6.07 were expected (SIR = 3.13, 95% confidence interval [CI] = 1.88 to 4.89; P<.001), and one case of ovarian cancer was diagnosed, whereas only 0.66 was expected (SIR = 1.52, 95% CI = 0.02 to 8.46; P = .48). These results suggest that women from BRCA mutation-negative, site-specific breast cancer families are not at increased risk for ovarian cancer. © The Author 2005. Published by Oxford University Press. All rights reserved. |
| Keywords: | adult; aged; middle aged; gene mutation; major clinical study; genetics; mutation; cancer risk; united states; follow up; follow-up studies; cancer incidence; prospective study; prospective studies; genetic analysis; ovarian neoplasms; cancer susceptibility; genetic predisposition to disease; ovary cancer; breast cancer; statistics; incidence; cohort analysis; odds ratio; risk factors; cancer screening; breast neoplasms; brca1 protein; brca2 protein; risk factor; high risk patient; risk assessment; questionnaires; risk; confidence interval; confidence intervals; questionnaire; tumor suppressor gene; statistical analysis; genes, brca1; genes, brca2; genetic susceptibility; breast tumor; ovary tumor; cancer registry; seer program; familial cancer; genetic risk; genetic predisposition; genetic screening; jews; jew |
| Journal Title: | JNCI: Journal of the National Cancer Institute |
| Volume: | 97 |
| Issue: | 18 |
| ISSN: | 0027-8874 |
| Publisher: | Oxford University Press |
| Date Published: | 2005-09-21 |
| Start Page: | 1382 |
| End Page: | 1384 |
| Language: | English |
| DOI: | 10.1093/jnci/dji281 |
| PUBMED: | 16174860 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 38" - "Export Date: 24 October 2012" - "CODEN: JNCIA" - "Source: Scopus" |
