Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-α (TGFA) gene and risk of oral cancer in Puerto Rico Journal Article
| Authors: | Kang, D.; Gridley, G.; Huang, W. Y.; Engel, L. S.; Winn, D. M.; Brown, L. M.; Bravo-Otero, E.; Wu, T.; Diehl, S. R.; Hayes, R. B. |
| Article Title: | Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-α (TGFA) gene and risk of oral cancer in Puerto Rico |
| Abstract: | Objectives and methods: Risks of oral cancer related to a CA microsatellite repeat polymorphism in intron 1 of the epidermal growth factor receptor (EGFR) gene and a TaqI polymorphism in the transforming growth factor-α (TGFA) gene were evaluated in a population-based case-control study consisting of 157 cases and 149 controls recruited in Puerto Rico. Results: Carriers of ≥ 16 CA repeats in EGFR showed a 1.9-fold increased risk for oral cancer (OR=1.9, 95% CI=1.0-3.5). Risks also tended to increase with decreasing number of alleles with ≥ 16 CA repeats (P for trend=0.06). Our data suggested a non-significant reduction in risk for subjects heterozygous for the TGFA polymorphism (OR=0.6, 95% CI=0.2-1.3). Conclusions: The EGFR-associated risk appeared to be independent of tobacco and alcohol use and may be restricted primarily to subjects who consumed low amounts of fresh fruits and vegetables (OR=5.9, 95% CI: 2.3-15.2). These data implicate dietary and molecular targets for oral cancer prevention. © 2005 Lippincott Williams & Wilkins. |
| Keywords: | adult; controlled study; human tissue; aged; middle aged; major clinical study; case control study; case-control studies; cancer risk; allele; cancer prevention; epidermal growth factor receptor; genotype; intron; risk factors; smoking; microsatellite dna; population research; heterozygosity; fruit; vegetable; vegetables; egfr; nicotiana tabacum; dietary intake; alcohol consumption; polymorphism, genetic; mouth neoplasms; mouth cancer; transforming growth factor alpha; dna polymorphism; microsatellite repeats; oral cancer; genes, erbb-1; puerto rico; tgfa; alcoholic beverages |
| Journal Title: | Pharmacogenetics and Genomics |
| Volume: | 15 |
| Issue: | 5 |
| ISSN: | 1744-6872 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2005-05-01 |
| Start Page: | 343 |
| End Page: | 347 |
| Language: | English |
| PUBMED: | 15864136 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 24 October 2012" - "Source: Scopus" |
