A microRNA polycistron as a potential human oncogene Journal Article

   


Authors: He, L.; Thomson, J. M.; Hemann, M. T.; Hernando Monge, E.; Mu, D.; Goodson, S.; Powers, S.; Cordon-Cardo, C.; Lowe, S. W.; Hannon, G. J.; Hammond, S. M.
Article Title: A microRNA polycistron as a potential human oncogene
Abstract: To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene.
Keywords: gene cluster; genetics; molecular genetics; mouse; phenotype; animal; metabolism; animals; mice; gene; apoptosis; clusters; genes; microrna; gene expression; biology; gene expression profiling; cell line; gene locus; cell line, tumor; oncology; carcinogenesis; oncogenes; disease model; rna; gene expression regulation; oncogene; b cell lymphoma; gene expression regulation, neoplastic; lymphoma, b-cell; molecular sequence data; messenger rna; tumors; rna, messenger; myc protein; lymphoma cell; genes, myc; tumor cell line; lymphoma; hematopoietic stem cell; micrornas; disease models, animal; oncogene c myc; proto-oncogene proteins c-myc; oncogene myc; multigene family; cells; living systems studies; human engineering; human oncogene; mir-17-92 polycistron; cistron
Journal Title: Nature
Volume: 435
Issue: 7043
ISSN: 0028-0836
Publisher: Nature Publishing Group  
Date Published: 2005-06-09
Start Page: 828
End Page: 833
Language: English
DOI: 10.1038/nature03552
PROVIDER: scopus
PUBMED: 15944707
PMCID: PMC4599349
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-20444467290&partnerID=40&md5=ec8657569c332e8921598e0e4feae936
Notes: --- - "Cited By (since 1996): 1407" - "Export Date: 24 October 2012" - "CODEN: NATUA" - "Molecular Sequence Numbers: GENBANK: GSM45026, GSM45027, GSM45028, GSM45029, GSM45030, GSM45031, GSM45032, GSM45033, GSM45034, GSM45035, GSM45036, GSM45037, GSM45038, GSM45039, GSM45040, GSM45041, GSM45042, GSM45043, GSM45044, GSM45045, GSM45046, GSM45047, GSM45048, GSM45049, GSM45050, GSM45051, GSM45052, GSM45053, GSM45054, GSM45055, GSM45056, GSM45057, GSM45058, GSM45059, GSM45060, GSM45061, GSM45062, GSM45063, GSM45064, GSM45065;" - "Source: Scopus"
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MSK Authors
  1. Eva M Hernando
    22 Hernando
  2. Carlos Cordon-Cardo
    612 Cordon-Cardo
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