Accelerated whole breast irradiation with intensity-modulated radiotherapy to the prone breast Journal Article
| Authors: | Croog, V. J.; Wu, A. J.; McCormick, B.; Beal, K. P. |
| Article Title: | Accelerated whole breast irradiation with intensity-modulated radiotherapy to the prone breast |
| Abstract: | Purpose: Whole breast irradiation (WBI) is the standard of care for patients with early-stage breast cancer who opt for breast conservation. After a randomized trial demonstrated equivalent cosmesis and disease control with accelerated WBI (AWBI), our institution began to offer AWBI to appropriate patients. The aim of this study was to examine our unique experience with AWBI using prone positioning and simplified intensity-modulated radiotherapy (IMRT) planning with a sequential boost to the tumor bed. Methods and Materials: We identified 356 patients who had been treated with prone WBI using IMRT in our department between January 2004 and December 2006. Of these, 128 (36%) patients had received AWBI (representing 131 treated breasts), consisting of 16 daily fractions of 265 cGy to a total dose of 4,240 cGy followed by a conventionally fractionated boost. Results: Patients who opted for AWBI were similar demographically to the patients undergoing conventional WBI. In the AWBI cohort, 83% of the patients had Stage T1 disease and 22% had nodal involvement (N1). The tumors were estrogen receptor-positive, progesterone receptor-positive and Her-2/Neu-amplified in 82%, 69%, and 11%, respectively. The median duration of AWBI plus a boost was 29 days, and no patient required a toxicity-related treatment break. No Grade 3 or greater acute toxicity developed. At a median follow-up of 18 months, one ipsilateral breast recurrence developed that was salvaged with mastectomy and immediate reconstruction. Conclusion: AWBI to the prone breast using simplified IMRT with a sequential boost offers women requiring breast-only adjuvant radiotherapy an abbreviated treatment with early tumor control and cosmesis comparable to that with standard fractionation. |
| Keywords: | adult; treatment outcome; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; fatigue; cancer recurrence; intensity modulated radiation therapy; doxorubicin; fluorouracil; paclitaxel; adjuvant therapy; radiation dose; methotrexate; cancer staging; follow up; edema; breast cancer; mastectomy; radiotherapy dosage; radiotherapy; epidermal growth factor receptor 2; cyclophosphamide; breast neoplasms; breast reconstruction; dose-response relationship, radiation; pruritus; intensity-modulated radiotherapy; physical therapy; tumors; adjuvant chemotherapy; irradiation; dermatitis; radiotherapy, conformal; estrogen receptor; progesterone receptor; accelerated whole breast irradiation; boost; cosmesis; fractionation; prone breast; patient treatment; toxicity; turbulent flow; disease control; trastuzumab; acute toxicity; body posture; dose fractionation |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 73 |
| Issue: | 1 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-01-01 |
| Start Page: | 88 |
| End Page: | 93 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2008.04.036 |
| PUBMED: | 18676095 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: IOBPD" - "Source: Scopus" |
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