Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis Journal Article
| Authors: | Gertz, M. A.; Comenzo, R.; Falk, R. H.; Fermand, J. P.; Hazenberg, B. P.; Hawkins, P. N.; Merlini, G.; Moreau, P.; Ronco, P.; Sanchorawala, V.; Sezer, O.; Solomon, A.; Grateau, G. |
| Article Title: | Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis |
| Abstract: | We undertook this study to develop uniformly accepted criteria for the definition of organ involvement and response for patients on treatment protocols for immunoglobulin light-chain amyloidosis (AL). A consensus panel was convened comprising 13 specialists actively involved in the treatment of patients with amyloidosis. Institutional criteria were submitted from each, and a consensus was developed defining each organ involved and the criteria for response. Specific criteria have been developed with agreed on definitions of organ and hematologic response as a result of discussions at the 10th International Symposium on Amyloid and Amyloidosis held in Tours, France, April 2004. These criteria now form the working definition of involvement and response for the purposes of future data collection and reporting. We report criteria that centers can now use to define organ involvement and uniform response criteria for reporting outcomes in patients with light-chain AL. © 2005 Wiley-Liss, Inc. |
| Keywords: | treatment outcome; disease course; histopathology; doxorubicin; liver function; conference paper; technetium 99m; aprotinin; lung disease; peripheral neuropathy; differential diagnosis; dexamethasone; melphalan; vincristine; amyloidosis; dimethyl sulfoxide; kidney function; organ specificity; liver disease; electromyography; thorax radiography; physical examination; radioisotope; corticosteroid; lung function; endoscopic biopsy; immunoglobulin light chain; immunoglobulin light chains; nerve function; lung biopsy; gastrointestinal disease; liver biopsy; kidney biopsy; heart amyloidosis; autonomic neuropathy; soft tissue disease; france; colchicine; heart function; amyloid; primary systemic amyloidosis; kidney amyloidosis; nerve conduction; doppler echocardiography; amyloid, organ involvement; amyloid, response to treatment; amyloid p component; immunoglobulin light chain amyloidosis |
| Journal Title: | American Journal of Hematology |
| Volume: | 79 |
| Issue: | 4 |
| ISSN: | 0361-8609 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2005-08-01 |
| Start Page: | 319 |
| End Page: | 328 |
| Language: | English |
| DOI: | 10.1002/ajh.20381 |
| PUBMED: | 16044444 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 212" - "Export Date: 24 October 2012" - "CODEN: AJHED" - "Source: Scopus" |
