| Abstract: |
Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN. © Springer-Verlag 2005. |
| Keywords: |
immunohistochemistry; controlled study; human tissue; protein expression; clinical feature; histopathology; pancreatic neoplasms; tumor localization; classification; intraductal papillary mucinous tumor; carcinoma, pancreatic ductal; tumor markers, biological; immunoenzyme techniques; nomenclature; mucin 1; tumor classification; fluorescent antibody technique, indirect; mucins; mucin 5ac; mucin 2; pancreatic tumor; intraductal papillary-mucinous neoplasm; muc; cystadenocarcinoma, mucinous; cystadenocarcinoma, papillary
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