Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance Journal Article
| Authors: | Djurkovic, S.; Loeffler, J. M.; Fischetti, V. A. |
| Article Title: | Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance |
| Abstract: | A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain. Copyright © 2005, American Society for Microbiology. All Rights Reserved. |
| Keywords: | unclassified drug; nonhuman; in vitro study; drug synergism; biological activity; gentamicin; azithromycin; levofloxacin; antibiotic sensitivity; streptococcus pneumoniae; minimum inhibitory concentration; bactericidal activity; bacteriophage; penicillin resistance; microbial sensitivity tests; hydrolase; penicillin g; penicillins; bacteriophage lytic enzyme; cpl 1 protein; synergistic activity; gentamicins; n-acetylmuramoyl-l-alanine amidase |
| Journal Title: | Antimicrobial Agents and Chemotherapy |
| Volume: | 49 |
| Issue: | 3 |
| ISSN: | 0066-4804 |
| Publisher: | American Society for Microbiology |
| Date Published: | 2005-03-01 |
| Start Page: | 1225 |
| End Page: | 1228 |
| Language: | English |
| DOI: | 10.1128/aac.49.3.1225-1228.2005 |
| PUBMED: | 15728935 |
| PROVIDER: | scopus |
| PMCID: | PMC549239 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 33" - "Export Date: 24 October 2012" - "CODEN: AMACC" - "Source: Scopus" |
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