Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance Journal Article


Authors: Djurkovic, S.; Loeffler, J. M.; Fischetti, V. A.
Article Title: Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance
Abstract: A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Keywords: unclassified drug; nonhuman; in vitro study; drug synergism; biological activity; gentamicin; azithromycin; levofloxacin; antibiotic sensitivity; streptococcus pneumoniae; minimum inhibitory concentration; bactericidal activity; bacteriophage; penicillin resistance; microbial sensitivity tests; hydrolase; penicillin g; penicillins; bacteriophage lytic enzyme; cpl 1 protein; synergistic activity; gentamicins; n-acetylmuramoyl-l-alanine amidase
Journal Title: Antimicrobial Agents and Chemotherapy
Volume: 49
Issue: 3
ISSN: 0066-4804
Publisher: American Society for Microbiology  
Date Published: 2005-03-01
Start Page: 1225
End Page: 1228
Language: English
DOI: 10.1128/aac.49.3.1225-1228.2005
PUBMED: 15728935
PROVIDER: scopus
PMCID: PMC549239
DOI/URL:
Notes: --- - "Cited By (since 1996): 33" - "Export Date: 24 October 2012" - "CODEN: AMACC" - "Source: Scopus"
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