Safety and efficacy of preoperative portal vein embolization with polyvinyl alcohol in 58 patients with liver metastases Journal Article

  


Authors: Covey, A. M.; Tuorto, S.; Brody, L. A.; Sofocleous, C. T.; Schubert, J.; Von Tengg Kobligk, H.; Getrajdman, G. I.; Schwartz, L. H.; Fong, Y.; Brown, K. T.
Article Title: Safety and efficacy of preoperative portal vein embolization with polyvinyl alcohol in 58 patients with liver metastases
Abstract: OBJECTIVE. The objective of our study was to evaluate the safety and efficacy of transhepatic lobar portal vein embolization (PVE) using polyvinyl alcohol (PVA) particles to induce contralateral lobar hypertrophy in patients with liver-only metastases and normal underlying liver function. MATERIALS AND METHODS. Fifty-eight consecutive patients with small predicted future liver remnants (FLRs) underwent PVE with PVA particles to induce hypertrophy of the contralateral hemi-liver before surgical resection of liver metastases. Total liver, right hemi-liver, and left hemi-liver volumes were calculated before and after embolization using a 3D workstation. RESULTS. Eight patients underwent left PVE; 47, right PVE; and three, right and segment IV PVE. There were no major complications of the procedure. The mean increases in the ratio of the FLR to the total estimated liver volume after right, right and segment IV, and left PVE were 9%, 10%, and 3%, respectively; the corresponding mean hypertrophy ratios were 24.3%, 31.9%, and 1.5%, respectively. CONCLUSION. Right PVE using PVA particles alone as the embolic agent is safe and effective in achieving left hemi-liver hypertrophy. In contrast, left PVE did not induce significant right hemi-liver hypertrophy in this patient population. © American Roentgen Ray Society.
Keywords: adult; treatment outcome; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; artificial embolism; liver function; liver neoplasms; preoperative care; methodology; metastasis; computer assisted tomography; tomography, x-ray computed; retrospective study; risk assessment; liver metastasis; three dimensional imaging; imaging, three-dimensional; liver tumor; interventional radiology; radiography, interventional; radiography; safety; liver function test; non invasive procedure; technique; portal vein; embolization, therapeutic; liver weight; liver function tests; polyvinyl alcohol; phlebography
Journal Title: American Journal of Roentgenology
Volume: 185
Issue: 6
ISSN: 0361-803X
Publisher: American Roentgen Ray Society  
Date Published: 2005-12-01
Start Page: 1620
End Page: 1626
Language: English
DOI: 10.2214/ajr.04.1593
PUBMED: 16304024
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33644826590&partnerID=40&md5=405f0528993d5001b0b7672ae2a60471
Notes: --- - "Cited By (since 1996): 25" - "Export Date: 24 October 2012" - "CODEN: AJROA" - "Source: Scopus"
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MSK Authors
  1. George I Getrajdman
    118 Getrajdman
  2. Lawrence H Schwartz
    306 Schwartz
  3. Anne Covey
    165 Covey
  4. Yuman Fong
    775 Fong
  5. Lynn Brody
    119 Brody
  6. Karen T Brown
    178 Brown
  7. Constantinos T Sofocleous
    244 Sofocleous
  8. Scott J Tuorto
    24 Tuorto
  9. Johanna Schubert
    12 Schubert
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