Antibody-based therapies for colorectal cancer Journal Article
| Authors: | Chung, K. Y.; Saltz, L. B. |
| Article Title: | Antibody-based therapies for colorectal cancer |
| Abstract: | The recent successful development of novel monoclonal antibodies that target key components of biologic pathways has expanded the armamentarium of treatment options for patients with colorectal cancer. Two targets in particular-the process of new blood vessel development, or angiogenesis, and the epidermal growth factor receptor and its signaling pathway-are exploited by the newest monoclonal antibodies that are available for use in colorectal cancer patients. This clinical review focuses on the defining role of the two most clinically advanced novel agents, bevacizumab (Avastin®; Genentech, Inc., South San Francisco, CA, http://www.gene.com) and cetuximab (Erbitux®; ImClone Systems, Inc., New York, http://www.imclone.com), in colorectal cancer. ©AlphaMed Press. |
| Keywords: | signal transduction; epidermal growth factor; survival rate; clinical trial; neutropenia; review; bevacizumab; erlotinib; fluorouracil; diarrhea; hypertension; side effect; skin toxicity; drug targeting; skin manifestation; capecitabine; neurotoxicity; colorectal cancer; cancer immunotherapy; bleeding; leukopenia; nausea; vomiting; epidermal growth factor receptor; receptor, epidermal growth factor; angiogenesis; cetuximab; monoclonal antibodies; irinotecan; monoclonal antibody; panitumumab; asthenia; rash; lung embolism; colorectal neoplasms; antibodies, monoclonal; heart infarction; thromboembolism; folinic acid; stomach ulcer; thrombosis; acne; gefitinib; transient ischemic attack; oxaliplatin; anaphylaxis; digestive system perforation; epistaxis; proteinuria; allergic reaction; artery thrombosis; cerebrovascular accident; epidermal growth factor receptor kinase inhibitor; matuzumab; angina pectoris |
| Journal Title: | The Oncologist |
| Volume: | 10 |
| Issue: | 9 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2005-10-01 |
| Start Page: | 701 |
| End Page: | 709 |
| Language: | English |
| DOI: | 10.1634/theoncologist.10-9-701 |
| PUBMED: | 16249350 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 36" - "Export Date: 24 October 2012" - "CODEN: OCOLF" - "Source: Scopus" |
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