Influence of type of cigarette on peripheral versus central lung cancer Journal Article
| Authors: | Brooks, D. R.; Austin, J. H. M.; Heelan, R. T.; Ginsberg, M. S.; Shin, V.; Olson, S. H.; Muscat, J. E.; Stellman, S. D. |
| Article Title: | Influence of type of cigarette on peripheral versus central lung cancer |
| Abstract: | Objectives: Adenocarcinoma has replaced squamous cell carcinoma as the most common cell type of lung cancer in the United States. It has been proposed that this shift is due to the increased use of filter and lower-tar cigarettes, resulting in increased delivery of smoke to peripheral regions of the lungs, where adenocarcinoma usually occurs. We reviewed radiologic data to evaluate the hypothesis that tumors in smokers of cigarettes with lower-tar yield are more likely to occur peripherally than tumors in smokers of higher-yield cigarettes. Methods: At two urban academic medical centers, we reviewed computed tomographic scans, chest radiographs, and medical records to assign tumor location (peripheral or central) for 330 smokers diagnosed with carcinoma of the lung between 1993 and 1999. We compared the proportion of tumors in a peripheral versus central location by lifetime filter use and average lifetime tar rating (<21 and ≥21 mg). Results: Tumor location (69% peripheral and 31% central) was unrelated to cigarette filter use. Smokers of cigarettes with lower-tar ratings were more likely than those with higher ratings to have peripheral rather than central tumors (odds ratio, 1.76; 95% confidence interval, 0.89-3.47). When restricted to subjects with adenocarcinomaior squamous cell carcinoma, the odds ratio (95% confidence interval) was 2.31 (1.05-5.08). Conclusions: Among cigarette smokers with lung cancer, use of cigarettes with lower-tar yield was associated with preferential occurrence of tumors in peripheral sites. Our findings support the hypothesis that changes in smoking associated with lower-tar cigarettes have led to a shift in the location of smoking-related lung cancer. Copyright © 2005 American Association for Cancer Research. |
| Keywords: | adult; aged; middle aged; major clinical study; case-control studies; cancer localization; cigarette smoking; cancer risk; united states; computer assisted tomography; image analysis; lung neoplasms; odds ratio; smoking; tomography, x-ray computed; confidence interval; lung adenocarcinoma; medical record; lung carcinoma; thorax radiography; lung squamous cell carcinoma; lifespan; filter; tars; urban area; tar |
| Journal Title: | Cancer Epidemiology Biomarkers and Prevention |
| Volume: | 14 |
| Issue: | 3 |
| ISSN: | 1055-9965 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2005-03-01 |
| Start Page: | 576 |
| End Page: | 581 |
| Language: | English |
| DOI: | 10.1158/1055-9965.epi-04-0468 |
| PUBMED: | 15767332 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 27" - "Export Date: 24 October 2012" - "CODEN: CEBPE" - "Source: Scopus" |
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