Agminated acquired melanocytic nevi of the common and dysplastic type Journal Article
| Authors: | Bragg, J. W.; Swindle, L.; Halpern, A. C.; Marghoob, A. A. |
| Article Title: | Agminated acquired melanocytic nevi of the common and dysplastic type |
| Abstract: | We previously reported a single case of agminated acquired melanocytic nevi, consisting of a localized clustering of banal and atypical moles. We now report 4 more cases, confirming that the initial case was not an isolated finding. We examined the lesions clinically, with a dermoscope, with a Wood's light, and in 3 cases with UV photography so as to exclude nevus spilus from the differential diagnosis. The presence of an underlying dysplastic nevus syndrome phenotype in 4 of the 5 cases raises the possibility that agminated nevi arise as a consequence of postzygotic loss of heterozygosity and, thus, may represent a type 2 segmental manifestation of the atypical mole syndrome phenotype. Further studies of similar cases using microdissection techniques for analysis of loss of heterozygosity pattern are warranted. |
| Keywords: | adult; clinical article; human tissue; skin manifestation; genetic analysis; ultraviolet radiation; phenotype; melanoma; skin biopsy; skin neoplasms; differential diagnosis; skin cancer; genetic association; cancer screening; epiluminescence microscopy; melanocytic nevus; nevus, pigmented; heterozygosity loss; physical examination; dysplastic nevus; microdissection; hypopigmentation; lentigo; agminated acquired melanocytic nevus |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 52 |
| Issue: | 1 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2005-01-01 |
| Start Page: | 67 |
| End Page: | 73 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2004.05.033 |
| PUBMED: | 15627083 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 16" - "Export Date: 24 October 2012" - "CODEN: JAADD" - "Source: Scopus" |
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